Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay+3 more
wiley +1 more source
Role of ammonium in the ionization of phosphatidylcholines during electrospray mass spectrometry. [PDF]
Rush MD, van Breemen RB.
europepmc +1 more source
Hologenomics Reveals Specialized Dietary Adaptations in the Mengla Snail‐Eating Snake
Dietary adaptation studies from a holobiome perspective are scarce beyond mammals. This research reveals how genomic and microbial interactions drive dietary specialization in the Mengla snail‐eating snake, with evidence of gut symbiont convergence between reptiles and mammals.
Chaochao Yan+10 more
wiley +1 more source
Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study. [PDF]
Chandasana H+3 more
europepmc +1 more source
Electrospray Ionisation Mass Spectrometry (ESI-MS): a powerful tool for the evaluation of chiral recognition in host-guest complexation [PDF]
Hélène Nierengarten+4 more
openalex +1 more source
Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang+15 more
wiley +1 more source
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong+9 more
wiley +1 more source
Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. [PDF]
Pal R+5 more
europepmc +1 more source
Electrospray ionization mass spectrometry of zinc, cadmium, and copper metallothioneins: Evidence for metal‐binding cooperativity [PDF]
Peter Gehrig+6 more
openalex +1 more source