Results 71 to 80 of about 260,257 (350)

Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain. A study using electrospray ionization mass spectrometry and fluorescence binding studies [PDF]

, 2002
Advances in understanding how GroEL binds to non-native proteins are reported. Conformational flexibility in the GroEL apical domain, which could account for the variety of substrates that GroEL binds, is illustrated by comparison of several independent ...
Adams, Boisvert, Braig, Braig, Brinker, Brocchierei, Brunger, Brunger, Buckle, Bukau, Chatellier, Chatellier, Chatellier, Chen, Collaborative Computational Project, N., Coyle, Dessauer, Ewalt, Feltham, Fenton, Ferrige, Grallert, Hartl, Hartl, HayerHartl, Hemmingsen, Hlodan, Houry, Hunt, Hutchinson, Jancarik, Jones, Jones, Kobayashi, Konermann, Kraunsoe, Kusmierczyk, Landry, Landry, Leslie, Loo, Ma, Murshudov, Navaza, Pace, Pflugrath, Ploegman, Raftery, Ranson, Robinson, Romano, Roseman, Rye, Sigler, Smith, Smote, Tanaka, Wang, Weber, Weber, Weissman, Xu, Zahn   +62 more
core   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Comparison of Two Detection Methods for Fragment Ions of Escherichia coli Carbon Center Metabolites

Journal of Pure and Applied Microbiology, 2018
Mass spectrometry is an analytical technique for molecules detection after separating the particle motion (charged molecules, atoms and fragment ions) according to their mass-to-charge ratio, under the action of an electric field and a magnetic field ...
Bin Rui, Xiaotao Wei, Long Chen, Yun An, Han Wen   +4 more
doaj   +1 more source

Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. [PDF]

, 2019
Although the evolutionary significance of the early-diverging flowering plant Amborella (Amborella trichopoda Baill.) is widely recognized, its metabolic landscape, particularly specialized metabolites, is currently underexplored.
Chang, Lijing, Tian, Li, Wilson, Alexander E, Wu, Sheng   +3 more
core   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

Studies on Transition Metal-Quercetin Complexes Using Electrospray Ionization Tandem Mass Spectrometry

Molecules, 2015
To systematically study the effects of the number of d electrons of the first transition metal ions (Fe, Co, Ni, Cu and Zn) on the formation and stability of metal flavonoid complexes, we took the quercetin/M2+ complex as a model system to investigate ...
Yuanzhen Liu, Mingquan Guo
doaj   +1 more source

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, EarlyView.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

High‐speed countercurrent chromatography fractionation of neolignans and phenylpropanoids by off‐line electrospray mass spectrometry injection profiling of Myristica fragrans [PDF]

, 2023
H. Präßler, Peter C. Will, Mieke M. B. Commandeur, Peter Winterhalter, Gerold Jerz   +4 more
openalex   +1 more source

Ozone Oxidizes Glutathione to a Sulfonic Acid [PDF]

, 2009
Biosurfaces are universally covered with fluid microfilms containing reduced glutathione (GSH) and other antioxidants whose putative roles include the detoxification of ambient ozone (O_3).
Colussi, A. J., Enami, Shinichi, Hoffmann, M. R.   +2 more
core   +1 more source

Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization [PDF]

, 2017
Background Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For
Alcaro, Stefano, Artese, Anna, Costa, Giosu\ue8, Distinto, Simona, Maccioni, Elias, Moraca, Federica, Nadai, Matteo, Ortuso, Francesco, Richter, Sara, Rocca, Roberta, Scalabrin, Matteo, Talarico, Carmine   +11 more
core   +1 more source