Results 61 to 70 of about 307,007 (266)

Closed-Loop Control of Electro-Ribbon Actuators

Frontiers in Robotics and AI, 2020
Electro-ribbon actuators are lightweight, flexible, high-performance actuators for next generation soft robotics. When electrically charged, electrostatic forces cause the electrode ribbons to progressively zip together through a process called ...
Richard Suphapol Diteesawat, Richard Suphapol Diteesawat, Aaron Fishman, Aaron Fishman, Tim Helps, Tim Helps, Majid Taghavi, Majid Taghavi, Jonathan Rossiter, Jonathan Rossiter   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Machine learning predictions of IgG1 and IgG4 self-association and high-concentration solution properties

mAbs
To meet the widespread demand for subcutaneous delivery of antibody therapeutics, candidates with low viscosity, high solubility, and/or low aggregation propensity in concentrated formulations must be identified.
Na-Young Kwon, Chloe N. Brown, Hsin-Ting Chen, Steven R. Cottle, Ronan M. Kelly, Bryan E. Jones, William F. Weiss, Peter M. Tessier   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

MEMS-Based Power Generation Techniques for Implantable Biosensing Applications

Sensors, 2011
Implantable biosensing is attractive for both medical monitoring and diagnostic applications. It is possible to monitor phenomena such as physical loads on joints or implants, vital signs, or osseointegration in vivo and in real time ...
Jonathan Lueke, Walied A. Moussa
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effects of Air Gaps on the Output Force Density in COMSOL Simulations of Biomimetic Artificial Muscles

Applied Sciences
This paper presents a novel approach to enhancing the performance of artificial muscle fibers by incorporating air gaps within the bulk dielectric material.
Michelangelo A. Coltelli, Emil P. Kartalov   +1 more
doaj   +1 more source

Electrostatic Defrosting

Small Methods
Abstract Electrification of ice has been studied for over half a century, mostly in the context of atmospheric science. Here, the polarizability and natural thermovoltage of a substrate‐bound frost sheet are exploited for frost removal by placing an actively charged electrode overhead.
Venkata Yashasvi Lolla, Hongwei Zhang, Beckett Z. Socha, Rui Qiao, Jonathan B. Boreyko   +4 more
openaire   +4 more sources