Results 51 to 60 of about 7,523,663 (244)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Electrostatic contributions to the kinetics and thermodynamics of protein assembly. [PDF]

, 2005
The role of electrostatic interactions in the assembly of a native protein structure was studied using fragment complementation. Contributions of salt, pH, or surface charges to the kinetics and equilibrium of calbindin D(9k) reconstitution was measured ...
Xue, Wei-Feng, Thulin E, Linse, Sara,, Thulin, Eva,, Linse S., Thulin, Eva, Xue, Wei-Feng,, Xue WF, Dell'Orco, Daniele, Dell'Orco, D, Linse, Sara, Lund University.   +11 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

ЕЛЕКТРОСТАТИЧНЕ ПОЛЕ В КАМЕРІ БАР’ЄРНОГО РОЗРЯДУ ДЛЯ ОЧИЩЕННЯ ВОДИ З УРАХУВАННЯМ ОКРЕМИХ ВОДНИХ КРАПЕЛЬ

Праці Інституту електродинаміки Національної академії наук України
The use of pulsed dielectric barrier discharge (DBD) for water purification via low-temperature plasma (LTP) is a promising technology. DBD enables the purification of water in a droplet-film state from organic contaminants by generating highly reactive ...
Р.С. Крищук
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Exact Partition Function for the Random Walk of an Electrostatic Field

Advances in Mathematical Physics, 2017
The partition function for the random walk of an electrostatic field produced by several static parallel infinite charged planes in which the charge distribution could be either ±σ is obtained. We find the electrostatic energy of the system and show that
Gabriel González
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

DETERMINATION OF THE EFFECTIVE PERMITTIVITY OF A HETEROGENEOUS MATERIAL

Electrical engineering & Electromechanics, 2020
Purpose. To develop a two-dimensional numerical-field model for determining the effective permittivity of a multicomponent material represented by a system of homogeneous volumes with known physical characteristics. Methodology. The model is based on the
O. O. Palchykov
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source