Results 61 to 70 of about 7,523,663 (244)
Applied SciencesProteins undergo a series of conformational changes when affected by the applied electric field, which changes their functions and properties. The conformational changes in proteins in various electric fields are different due to their internal ...
Mingyan Hou +6 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Calculation of the structure of electrostatic quadrupole-cylindrical fields
Қарағанды университетінің хабаршысы. Физика сериясы, 2018 The paper is devoted to the investigation of electrostatic quadrupole-cylindrical fields. Calculation of the structure of electrostatic quadrupole-cylindrical fields, synthesized on the basis of the sum of the base cylindrical field and axially ...
Zh.T. Kambarova, А.О. Saulebekov
doaj
Simulation Analysis of High Voltage Electrical Box Electric Field for Centralized Power EMUs
机车电传动, 2020 According to the principle of main circuit for centralized power EMUs in China, the high voltage electrical box equipped with two main circuit breakers was researched and designed, which not only optimized the arrangement of roof equipments, but also ...
Congjian JIANG, Tao LI, Yingyu YANG
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Electrodynamic Induction in Electrostatic Field [PDF]
, 2020 This paper described the principle of electrodynamic induction in the electric field. According to that principle, induced electric current in the perfect conductor that connects two plane-parallel metal plates is proportional to a rate of the flux ...
Cavelis, Marin
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
EnergiesInsulators in wind-sand flows distort the electric field along their surfaces due to the wind-sand electric field, threatening the safe operation of transmission lines.
Li Huang, Jiangjie Yin, Yan Zhao
doaj +1 more source
Electrostatic Force for Swarm Navigation and Reconfiguration [PDF]
, 2009 In this work the concept of a swarm of satellites controlled by a hybrid thrusting electrostatic actuation system is assessed. On one side the propulsion system is investigated.
Theil, Stephan +3 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source