Results 41 to 50 of about 167,750 (211)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Agronomy, 2023 In this study, we evaluated the effectiveness of hyperparasitic fungi in controlling powdery mildew (PM). In a greenhouse, we spray-inoculated single colonies of the melon PM-causing fungus Podosphaera xanthii strain KMP-6N at three different fungal ...
Yutaka Kimura +10 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Acta Acustica, 2022 A dynamic model for a double-bubble system in compressible liquid under the coupling effect of ultrasound and electrostatic field was developed here. In this study, we mainly discussed the effect of the interaction on the investigated bubble using the ...
Deng Jin-Jie, Yu Ming, Yang Ri-Fu
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Calculation of the structure of electrostatic quadrupole-cylindrical fields
Қарағанды университетінің хабаршысы. Физика сериясы, 2018 The paper is devoted to the investigation of electrostatic quadrupole-cylindrical fields. Calculation of the structure of electrostatic quadrupole-cylindrical fields, synthesized on the basis of the sum of the base cylindrical field and axially ...
Zh.T. Kambarova, А.О. Saulebekov
doaj
Applied SciencesProteins undergo a series of conformational changes when affected by the applied electric field, which changes their functions and properties. The conformational changes in proteins in various electric fields are different due to their internal ...
Mingyan Hou +6 more
doaj +1 more source
GENERALIZATION OF THE THOMSON FORMULA FOR HOMOGENEOUS HARMONIC FUNCTIONS
St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019 It is shown that the Thomson formula for three-dimensional harmonic homogeneous functions can be generalized if, instead of purely algebraic linear expressions, one uses a linear algebraic form with the participation of the first order partial ...
Berdnikov Alexander +3 more
doaj +1 more source
An influence of the petrol pump for the atmospheric electric field distribution in the surroundings of the vehicles [PDF]
Serbian Journal of Electrical Engineering, 2004 In this paper the potential and electric field distribution in the surroundings of the cargo vehicles is approximately numerically determined, when they are exposed to the Atmospheric Electric Field (AEF), having uniform intensity and vertical ...
Milovanović Alenka
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source