Results 41 to 50 of about 167,443 (258)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Machines, 2022 Electrostatic abrasive implantation technology is a classical process based on electrostatic field to implant abrasive particles into base material. However, there is still not a quantitative model to ensure the implantation performance due to the fact ...
Huifeng Zheng +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Calculation of the structure of electrostatic quadrupole-cylindrical fields
Қарағанды университетінің хабаршысы. Физика сериясы, 2018 The paper is devoted to the investigation of electrostatic quadrupole-cylindrical fields. Calculation of the structure of electrostatic quadrupole-cylindrical fields, synthesized on the basis of the sum of the base cylindrical field and axially ...
Zh.T. Kambarova, А.О. Saulebekov
doaj
Applied SciencesProteins undergo a series of conformational changes when affected by the applied electric field, which changes their functions and properties. The conformational changes in proteins in various electric fields are different due to their internal ...
Mingyan Hou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Simulation Analysis of High Voltage Electrical Box Electric Field for Centralized Power EMUs
机车电传动, 2020 According to the principle of main circuit for centralized power EMUs in China, the high voltage electrical box equipped with two main circuit breakers was researched and designed, which not only optimized the arrangement of roof equipments, but also ...
Congjian JIANG, Tao LI, Yingyu YANG
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GENERALIZATION OF THE THOMSON FORMULA FOR HOMOGENEOUS HARMONIC FUNCTIONS
St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019 It is shown that the Thomson formula for three-dimensional harmonic homogeneous functions can be generalized if, instead of purely algebraic linear expressions, one uses a linear algebraic form with the participation of the first order partial ...
Berdnikov Alexander +3 more
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source