Results 91 to 100 of about 35,013 (304)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Electrostatics generators [PDF]

, 2012
Title: Electrostatic generators Author: Michal Hnyk Department: Department of Physics Education Supervisor: doc. RNDr. Leoš Dvořák, CSc., Department of Physics Education Abstract: This bachelor thesis named Electrostatic generators is divided into four ...
Hnyk, Michal
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Electrostatics in Electrolytes Expressed in an Exact Formalism Reminiscent of the Poisson–Boltzmann Picture

, 2014
In the PB approximation for electrolyte systems one assumes that the solvent behaves like a dielectric continuum and that the charge of each ion interacts with the average electrostatic potential from other ions in the system, neglecting the correlations.
Kjellander, Roland,
core  

Guest editorial

, 2007
From the 13th to 16th of September, 2004 researchers active in the fields of physics of lightning and lightning protection gathered in Avignon, France for the 27th International Conference on Lightning Protection (ICLP).
Cooray, Vernon,, Rachidi, Farhad,, Nucci, Carlo Alberto,   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation

mAbs
Antibody therapeutics are a rapidly growing class of biopharmaceuticals, but concerns regarding potential developability issues persist. While complementarity-determining region (CDR) loops are imperative for antigen specificity and mutations are ...
Vera A. Spanke, Valentin J. Egger-Hoerschinger, Clarissa A. Seidler, Katharina B. Kroell, Vincent Wieser, Sabine Imhof-Jung, Benjamin Weiche, Alexander Bujotzek, Guy Georges, Klaus R. Liedl   +9 more
doaj   +1 more source

High-voltage electrostatic slides: Are they still relevant for teaching in the era of numerical simulations?

[EN] The teaching of electrostatics has been a cornerstone of physics and engineering education for centuries. Its focus has evolved significantly, transitioning from a 19th-century practical approach represented by Ganot's textbooks to a predominantly ...
Llovera Segovia, Pedro, Quijano-Lopez, Alfredo, Simon-Castel, Josep, Fuster Roig, Vicente Luis   +3 more
core   +1 more source