Results 81 to 90 of about 35,013 (304)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
eLife, 2018 TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca2+. This channel comprises two independent pores and closely apposed Ca2+ binding sites that are contained within each subunit of a homodimeric protein.
Andy KM Lam, Raimund Dutzler
doaj +1 more source
Electrostatics surface representation of 16055 NFL and different mAbs.
, 2021 Electrostatics surface representation of (A) 16055 NFL and (B) V1V2 and V2 region zooms (top and side views). Epitopes are highlighted by dotted lines and some residues in V2 are shown in stick and labeled.
Richard T. Wyatt (150723) +17 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A Practical, Quantitative Electrostatics Experiment
, 2019 An electrostatics experiment is presented that is practical, affordable, and quantitative. The equipment required is readily available and relatively inexpensive. The experiment relies on the electrostatic induction that results from a charged insulative
Armentrout, Bryan K., Castano, Diego
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Shotcreting with Cement–Sand Mixtures Under the Influence of an Electrostatic Field
BuildingsOne of the primary and still unresolved problems of shotcreting is the high rebound rate of the material, which reaches over 20% in “dry” shotcreting. There is a practical need to improve the very principle of shotcreting and methods for optimizing the ...
Valery Mishchenko +3 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
An Overview of Strengths and Directionalities of Noncovalent Interactions: σ-Holes and π-Holes
Crystals, 2019 Quantum mechanics, through the Hellmann–Feynman theorem and the Schrödinger equation, show that noncovalent interactions are classically Coulombic in nature, which includes polarization as well as electrostatics. In the great majority of these
Peter Politzer, Jane S. Murray
doaj +1 more source
Electrostatics does not dictate the slip-stacked arrangement of aromatic π–π interactions [PDF]
, 2020 Benzene dimer has long been an archetype for π-stacking. According to the Hunter-Sanders model, quadrupolar electrostatics favors an edge-to-face CH⋯π geometry but competes with London dispersion that favors cofacial π-stacking, with a compromise "slip ...
Carter-Fenk, Kevin, Herbert, John M
core +1 more source