Results 101 to 110 of about 35,013 (304)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Education SciencesThe method of images (MoI) is a valuable technique for solving certain electrostatic boundary value problems consisting of charge density near conductor(s).
Jaya Shivangani Kashyap +2 more
doaj +1 more source
Electrostatic pair-potentials based on the Poisson equation
New Journal of Physics, 2019 Electrostatic pair-potentials within molecular simulations are often based on empirical data, cancellation of derivatives or moments, or statistical distributions of image-particles.
B Stenqvist
doaj +1 more source
Electrostatics and hydrophobicity at the interface.
, 2014 Errors correspond to standard deviation.Electrostatics and hydrophobicity at the interface.
Dominique Madern (659600) +3 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Coulomb blockade model of permeation and selectivity in biological ion channels
New Journal of Physics, 2015 Biological ion channels are protein nanotubes embedded in, and passing through, the bilipid membranes of cells. Physiologically, they are of crucial importance in that they allow ions to pass into and out of cells, fast and efficiently, though in a ...
I Kh Kaufman +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Electrostatics in chemistry. 1. Basic principles
, 1996 Electrostatics plays an important role in weak intermolecular interactions. The present series is aimed at understanding these electrostatic aspects. This article presents the fundamental concepts of electrostatics as applied to atoms and molecules.
Bhadane, Pravin K., Gadre, Shridhar R.
core
On the Lagrangian electrostatics of elastic solids
, 2009 The equilibrium equations and the Maxwell equations of electrostatics are derived here through a variational procedure. All the treatment is expounded in the reference configuration of the deformed body and the electromagnetic quantities and equations of
TRIMARCO, CARMINE
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source