Results 91 to 100 of about 10,176,751 (287)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Rapid prototyping in medical sciences

Production Engineering Archives, 2015
Even if it sound a bit incredible rapid prototyping (RPT) as production method has been used for decades in other professions. Nevertheless medical science just started discover the possibilities of this technology and use the offered benefits of 3D ...
Ákos Márk Horváth, Péter Ficzere
doaj  

Some Missing Elements [PDF]

macroeconomics
Edward J. Lincoln
core  

Beneficial Elements

, 2012
This chapter focuses on the role played by beneficial elements such as sodium (Na), silicon (Si), cobalt (Co), selenium (Se), and aluminum (Al). Sodium can stimulate growth of plants, particularly some C4 plants by aiding the movement of substrates between the mesophyll and the bundle sheath.
Broadley, Martin, Brown, Patrick, Çakmak, İsmail, Ma, Jian Feng, Rengel, Zed, Zhao, Fangjie   +5 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Real-Time Prediction of Pressure and Film Height Distribution in Plain Bearings Using Physics-Informed Neural Networks (PINNs)

Lubricants
The increasing application of plain bearings in various industries, especially under challenging conditions like thin lubricating films and high temperatures, necessitates effective monitoring to prevent failures and ensure reliable performance.
Ahmed Saleh, Georg Jacobs, Dhawal Katre, Benjamin Lehmann, Mattheüs Lucassen   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Characterization of functional nanoparticles applied in face masks by STEM-EDX [PDF]

BIO Web of Conferences
Wouters Charlotte, Ledecq Marina, Morales Denrich, Tsilikas Khariklia, Ouf François-Xavier, Verleysen Eveline, Mast Jan   +6 more
doaj   +1 more source