Results 91 to 100 of about 4,915,083 (312)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Ireland Reimagined: Grasping Historial Perceptions for the Decade of Centenaries

open access: yes, 2022
Ireland's decade of centenaries (2012-2022) commemorates historial milestones that led to the country's independence from Great Britain and the creation of the Republic of Ireland.
Sepe, Czar, Elements
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Pronouns and Personhood: Exploring the Construction of Gender Identities from the Feminist Perspective

open access: yes, 2022
This paper argues that that to have gender is not having certain reproductive anatomy, but is instead the social meaning of sex. Gender has now become a social construct imposed upon the human person, thwarting their ability to identify as the social ...
Lenahan, Christine, Elements
core  

Frontier Elements: Connections with f-Elements [PDF]

open access: yes, 1985
In the last decade organo-f-element chemistry has developed almost explosively. Especially organometallic compounds with carbocyclic ligands of the cyclopentadienyl type (Cp = η5-C5H5, Cp* = η5-C5(CH3)5, and other substituted cyclopentadienyls) have attracted a great deal of attention.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

MAGNETITE DEPOSITS OF THE TOMTOR (ONKUCHAKH AREA) AND KOVDOR PLUTONS: A PROBLEM OF ORE PRECARBONATITES [PDF]

open access: yesМинералогия, 2018
The comparative characteristics of magnetite deposits of the Kovdor (camaphorite deposit) and Tomtor (Onkuchakh area) plutons, which were formed during the carbonatite stage of the formation of the plutons and can be classified «ore precarbonatites», is ...
A.V. Lapin   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Method for Real-Time Monitoring of the Lubrication Regimes in Dynamically Loaded Radial Sliding Bearings Using Physics-Informed Neural Networks (PINNs)

open access: yesLubricants
This study proposes a model-based method for real-time monitoring of the lubrication regimes in dynamically loaded radial sliding bearings using Physics-Informed Neural Networks (PINN).
Ahmed Saleh   +4 more
doaj   +1 more source

Thermal Turbulent Flow in Leading Edge Grooved and Conventional Tilting Pad Journal Bearing Segments—A Comparative Study

open access: yesLubricants, 2018
A comparative study between a conventional- and leading edge grooved (LEG) tilting pad journal bearing (TPJB) segment is performed. The developed model uses the Shear Stress Transport (SST) turbulence model, coupled with the energy equation and a partial
Philip Croné   +2 more
doaj   +1 more source

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