Results 61 to 70 of about 13,953 (184)

Western Anthelmintics in Early Twentieth‐Century China Colonial Practices and Knowledge on “Tropical Diseases” of the In/between**

Berichte zur Wissenschaftsgeschichte, Volume 47, Issue 4, Page 330-351, December 2024.
Abstract Protestant (medical) missionaries were the main proponents of Western medicine in China after the Opium Wars. Several studies have highlighted how they used spectacular surgery as a means of gaining public trust. As well as surgery, they also administered anthelmintic drugs such as santonin as a tool of persuasion and conversion.
Dominik Merdes
wiley   +1 more source

Prevalence of endemic Bancroftian filariasis in the high altitude region of south-eastern Nigeria [PDF]

Journal of Vector Borne Diseases, 2011
Background & objectives: The study was aimed at determining the prevalence and intensity of Wuchereriabancrofti microfilaraemia in a high altitude region of south-eastern Nigeria, and ascertaining the prevalenceof clinical signs and symptoms associated ...
E.C. Utta
doaj  

Insulin receptor knockdown blocks filarial parasite development and alters egg production in the southern house mosquito, Culex quinquefasciatus. [PDF]

PLoS Neglected Tropical Diseases, 2018
Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. Wuchreria bancrofti (Wb) is responsible for >90% of infections and the remainder are caused by Brugia spp.
Andrew Bradley Nuss, Mark R Brown, Upadhyayula Suryanarayana Murty, Monika Gulia-Nuss   +3 more
doaj   +1 more source

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

PLoS Biology, 2010
Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development.
Simon A Babayan, Andrew F Read, Rachel A Lawrence, Odile Bain, Judith E Allen   +4 more
doaj   +1 more source

The complexities of blood‐feeding patterns in mosquitoes and sandflies and the burden of disease: A minireview

Veterinary Medicine and Science, Volume 10, Issue 5, September 2024.
Mosquitoes and phlebotomine sandflies are infectious disease vectors through hematophagy. The development of hematophagy likely provided an evolutionary advantage, offering a rich nutrient source for reproduction. These insects exhibit diverse blood‐feeding patterns, from invertebrates to various vertebrates. Multiple sensory cues to guide host‐seeking
Fatma Bursali, Mustapha Touray
wiley   +1 more source

Isolated perinephric abscess as the initial manifestation of filariasis—an unusual presentation

Clinical Case Reports, Volume 12, Issue 3, March 2024.
Graphical Abstract Key Clinical Message Filariasis may present as an isolated perinephric abscess. Hence, a high index of suspicion should be maintained in endemic settings. Abstract In cases with unexplained fever, eosinophilia and perinephric collection, it is necessary to do detailed infectious disease work up. High index of suspicion is required to
Govind Sharma, Rajat Sachdeva, Shweta Aggarwal, Amogh Verma, Ayush Anand, Ajeet Singh, Prakasini Satapathy   +6 more
wiley   +1 more source

WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. [PDF]

PLoS Neglected Tropical Diseases, 2012
Lymphatic filariasis is caused by filarial nematode parasites, including Brugia malayi. Adult worms live in the lymphatic system and cause a strong immune reaction that leads to the obstruction of lymph vessels and swelling of the extremities.
Chris Marcellino, Jiri Gut, K C Lim, Rahul Singh, James McKerrow, Judy Sakanari   +5 more
doaj   +1 more source

A Clinico- Epidemiological Study Of Filarial Related Orthopaedic Manifestations

Indian Journal of Community Medicine, 1992
An epidemiological study was undertaken to study the incidence and distribution of orthopaedic manifestations of filariasis in an endemic area. A total of 207 cases were clinically examined and investigated. Patients were divided into three groups , viz.,
Patond K.R, Tandon V, Harinath B.C, Narang P, Srivastava S.K, Cheirmaraj K, Rao Rama B.V   +6 more
doaj  

Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3

BMC Genomics, 2009
Background Filarial nematode parasites cause serious diseases such as elephantiasis and river blindness in humans, and heartworm infections in dogs. Third stage filarial larvae (L3) are a critical stage in the life cycle of filarial parasites, because ...
Spiro David, Yin Yong, Mitreva Makedonka, Rush Amy C, Li Ben-Wen, Ghedin Elodie, Weil Gary J   +6 more
doaj   +1 more source