Results 61 to 70 of about 4,044 (214)

Genetic, Immunological, and Public Health Perspectives on Podoconiosis

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Podoconiosis is a neglected tropical disease (NTD) that primarily affects poor communities in tropical regions, particularly in sub‐Saharan African countries. The disease results from prolonged contact with red clay soils, leading to chronic lymphedema of the lower limbs.
Tsegahun Asfaw Abebe, Abiola Isawumi, Lipi Buch   +2 more
wiley   +1 more source

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

PLoS Biology, 2010
Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development.
Simon A Babayan, Andrew F Read, Rachel A Lawrence, Odile Bain, Judith E Allen   +4 more
doaj   +1 more source

Urban Lymphatic Filariasis in the Metropolis of\ud Dar es Salaam, Tanzania [PDF]

, 2013
The last decades have seen a considerable increase in urbanization in Sub-Saharan Africa, and it is estimated that over 50% of the population will live in urban areas by 2040.
Malecela, Mwelecele N, Mosha, Franklin W, Mwakitalu, Mbutolwe E, Pedersen, Erling M, Simonsen, Paul E   +4 more
core  

Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers [PDF]

, 2016
Background The suitability of using clinical assessment to identify patients with podoconiosis in endemic communities has previously been demonstrated. In this study, we explored the feasibility and accuracy of using Community Health Implementers (CHIs)
A Tora, Abdel Jelil Njouendou, Bridget A. Fovennso, D Yach, David D. Sofeu-Feugaing, DG Addiss, Dizzel Bita Tayong, E Cufino Svitone, EW Price, EW Price, F Tekola, F Tekola, Fabrice R. Datchoua-Poutcheu, Fasil Tekola-Ayele, G Davey, G Davey, Gail Davey, H Kloos, JA Kengne-Ouafo, JM Kelly, Jonas A. Kengne-Ouafo, K Deribe, K Deribe, K Deribe, K Destas, KS Jacob, L Gilson, MB Love, Melanie J. Newport, Nathalie Amvongo-Adjia, PA Berman, Peter A. Enyong, RK Shenoy, S Shawa, S Wanji, Samuel Wanji, TA Gaziano, The_C. D. I._Study_ Group, U Lehmann, W Sherrill, WHO, Yolande F. Longang-Tchounkeu   +41 more
core   +2 more sources

Western Anthelmintics in Early Twentieth‐Century China Colonial Practices and Knowledge on “Tropical Diseases” of the In/between**

Berichte zur Wissenschaftsgeschichte, Volume 47, Issue 4, Page 330-351, December 2024.
Abstract Protestant (medical) missionaries were the main proponents of Western medicine in China after the Opium Wars. Several studies have highlighted how they used spectacular surgery as a means of gaining public trust. As well as surgery, they also administered anthelmintic drugs such as santonin as a tool of persuasion and conversion.
Dominik Merdes
wiley   +1 more source

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source

Immune Responses to Filarial Nematodes: A Mechanistic Evaluation of Evasion and Modulation Strategies

Immuno
Filarial parasites are long-lived organisms that cause extreme morbidity due to pathological manifestations, including lymphedema, hydrocele, and elephantiasis.
Tripti Singh, Shivani Sharma, Animesh Tripathi, Sunil Kumar, Anchal Singh   +4 more
doaj   +1 more source

The complexities of blood‐feeding patterns in mosquitoes and sandflies and the burden of disease: A minireview

Veterinary Medicine and Science, Volume 10, Issue 5, September 2024.
Mosquitoes and phlebotomine sandflies are infectious disease vectors through hematophagy. The development of hematophagy likely provided an evolutionary advantage, offering a rich nutrient source for reproduction. These insects exhibit diverse blood‐feeding patterns, from invertebrates to various vertebrates. Multiple sensory cues to guide host‐seeking
Fatma Bursali, Mustapha Touray
wiley   +1 more source

Vulval elephantiasis as a result of tubercular lymphadenitis: two case reports and a review of the literature [PDF]

, 2010
Introduction Elephantiasis as a result of chronic lymphedema is characterized by gross enlargement of the arms, legs or genitalia, and occurs due to a variety of obstructive diseases of the lymphatic system.
null Chintamani, JP Singh, Megha Tandon, Rohan Khandelwal, Tushar Aeron, Sidharth Jain, Nikhil Narayan, Rahul Bamal, Yashwant Kumar, S Srinivas, Sunita Saxena   +10 more
core   +1 more source

Isolated perinephric abscess as the initial manifestation of filariasis—an unusual presentation

Clinical Case Reports, Volume 12, Issue 3, March 2024.
Graphical Abstract Key Clinical Message Filariasis may present as an isolated perinephric abscess. Hence, a high index of suspicion should be maintained in endemic settings. Abstract In cases with unexplained fever, eosinophilia and perinephric collection, it is necessary to do detailed infectious disease work up. High index of suspicion is required to
Govind Sharma, Rajat Sachdeva, Shweta Aggarwal, Amogh Verma, Ayush Anand, Ajeet Singh, Prakasini Satapathy   +6 more
wiley   +1 more source