Results 61 to 70 of about 716,525 (313)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
PLoS ONE, 2017 Understanding how elevated CO2 affects dynamics of nodal leaf growth and N assimilation is crucial for the construction of high-yielding canopy via breeding and N management to cope with the future climate change.
Jian Jin +7 more
doaj +1 more source
Impacts of elevated atmospheric CO₂ on nutrient content of important food crops. [PDF]
, 2015 One of the many ways that climate change may affect human health is by altering the nutrient content of food crops. However, previous attempts to study the effects of increased atmospheric CO2 on crop nutrition have been limited by small sample sizes and/
Bloom, Arnold J +21 more
core
Rising atmospheric CO2 concentration may imply higher risk of Fusarium mycotoxin contamination of wheat grains [PDF]
, 2017 2 Abstract Increasing atmospheric CO2 concentration not only has a direct impact on plants but also affects plant-pathogen interactions. Due to economic and health-related problems, special concern was given thus in the present work to the effect of ...
Balla, Krisztina +6 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Effect of elevated atmospheric CO2 level on the abiotic and biotic stress tolerance of cereals [PDF]
, 2013 Effect of elevated CO2 level (EC) was studied on the tolerance of cereals to elevated temperature and drought and on the resistance of wheat to fungal diseases. In general, elevated growth temperature did not affect final grain size, thus having less
Balla, Krisztina +4 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Assimilatory function and biochemical changes in Stylosanthes hamata grown under elevated CO2
Plant, Soil and Environment, 2012 We studied the impact of 360 ± 50 µL/l (ambient) and 600 ± 50 µL/L (elevated) CO2 on growth performance, biomass production, photosynthetic efficiency, carbon isotope discrimination, protein profile and some antioxidant enzymes on Stylosanthes hamata ...
M.J. Baig +3 more
doaj +1 more source
Ecological Processes, 2022 Background Atmospheric CO2 may double by the year 2100, thereby altering plant growth, photosynthesis, leaf nutrient contents and water relations. Specifically, atmospheric CO2 is currently 50% higher than pre-industrial levels and is projected to rise ...
Mthunzi Mndela +6 more
doaj +1 more source