Results 91 to 100 of about 84,293 (284)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

, 2014
("control") mice. Fetal and neonatal Notch2-cKO livers were devoid of cytokeratin19 (CK19)-, Dolichos-biflorus agglutinin (DBA)-, and SOX9-positive ductal structures, demonstrating absence of prenatal cholangiocyte differentiation.
Hakvoort, Theodorus B. M., Labruyere, Wilhelmina T., Lamers, Wouter H., Poncy, Alexis, Hakvoort, Theodorus B.M., Aronson, Daniël C., Weeda, Víola B., Falix, Farah A., Gaemers, Ingrid C., de Waart, Dirk R., Lemaigre, Frédéric   +10 more
core   +1 more source

Inflammatory Myofibroblastic Tumour of the Common Bile Duct

, 2022
Inflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin.
Mega, Raquel, Bilhim, Tiago, Carvalho, Ana, Almeida E Sousa, Matilde   +3 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Elevated ducting of radiowaves in association with trade wind Inversion along the coasts of India

MAUSAM, 1982
The present paper deals with the study of elevated radio ducts over seas along the east and west coasts of India in association with trade wind inversion during the months June  through September. This study was specially undertaken after a few reports of abnormal super-refraction and ducting phenomena near the Bombay coast during June-September 1974 ...
KALIPADA CHATTERJEE, S. MATHUR
openaire   +2 more sources

Concurrently Achieving 4.6 W/M2 and 120,000 Cyclability Enabled by Extendable Swing Arms in Rotational Triboelectric Nanogenerator

Advanced Science, EarlyView.
A rotational energy harvesting device that successfully reconciles high power density with mechanical durability through a hybrid sliding‐and‐bouncing kinematic mechanism is reported. The success reported in our paper includes addressing a dilemma where enhanced electrical output comes at the cost of increased friction and wear, limiting the practical ...
Yihong Lin, Jiaming Zhou, In‐Yong Suh, Eunjong Kim, Kin Chiu Yip, Dae‐jin Kim, Jang‐Mook Jeong, Young‐Jun Kim, Jinyoung Jeon, Ju‐Hyuck Lee, Yoon‐Hwae Hwang, Sang‐Woo Kim, Dong‐Myeong Shin   +12 more
wiley   +1 more source

Double trouble: A unique case of TRUS biopsy induced left upper moiety infection of a duplicated ectopic ureter

Urology Case Reports, 2019
Duplex collecting systems are seen in 0.7% of the population and its association with an ectopic ureter (specifically in the ejaculatory duct) is even less common.
Fares Kosseifi, Johnny Jean Baptiste, Raed El Samad, Jean-Claude Kikassa, Kamal Achkar   +4 more
doaj   +1 more source

Ret-Dependent Cell Rearrangements in the Wolffian Duct Epithelium Initiate Ureteric Bud Morphogenesis

, 2009
SummaryWhile the genetic control of renal branching morphogenesis has been extensively described, the cellular basis of this process remains obscure. GDNF/RET signaling is required for ureter and kidney development, and cells lacking Ret are excluded ...
Chi, Xuan, Shakya, Reena, Kato, Masashi, Michos, Odyssé, Riccio, Paul, Enomoto, Hideki, Asai, Naoya, Licht, Jonathan D., Costantini, Frank, Mendelsohn, Cathy, Takahashi, Masahide, Ohgami, Nobutaka   +11 more
core   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Diagnostic Challenges in Follicular Cholangitis Mimicking Hilar Cholangiocarcinoma: A Case Report and Review of the Literature

Medicina
Introduction: Distinguishing benign from malignant biliary strictures remains challenging despite diagnostic advancements. Follicular cholangitis, a rare benign condition, presents with symptoms and imaging similar to malignancies like cholangiocarcinoma,
Jungnam Lee, Seok Jeong, Don Haeng Lee, Suk Jin Choi, Woo Young Shin   +4 more
doaj   +1 more source