Results 131 to 140 of about 212,868 (349)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Elevator Control Simulation Using Fuzzy Logic Management
JuTISI (Jurnal Teknik Informatika dan Sistem Informasi)The use of a permanent magnet synchronous motor as an actuator in a ropeless elevator presents a number of difficulties that must be overcome for the system to be secure and stable.
Mehr Ali Qasimi, Asmatullah Nashir
doaj +1 more source
Elevating form and elevating modulation
Popular Music, 2014 AbstractThe device known as, among other terms, truck-driver modulation, arranger's modulation and pump-up modulation is an important procedure for popular music, and one that merits a place in the harmony textbook. Emerging from a discussion of nomenclature, this paper proposes the terms of its title, which distinguishes between modulation as part of ...
openaire +2 more sources
Dynamic Tension Analysis for Governor Rope in Elevator System
, 2018 Mitsuhiro Yamazumi +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Research on Distributed Fault Diagnosis Model of Elevator Based on PCA-LSTM
AlgorithmsA Distributed Elevator Fault Diagnosis System (DEFDS) is developed to tackle frequent malfunctions stemming from the widespread distribution and aging of elevator systems.
Chengming Chen +2 more
doaj +1 more source