Results 151 to 160 of about 295,389 (350)

EFFECTS OF CONSTANT AND ELF STRENGTH PROFILES ON THE PERFORMANCE OF WOOD FRAME SHEAR WALL STRUCTURES [PDF]

, 2023
Francisco X. Flores, Philip Line, Finley A. Charney   +2 more
openalex   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Effect of ELF-EMF on antioxidant status and micronuclei in K562 cells and normal lymphocytes [PDF]

, 2014
Branislava Srđenović Čonić, Jasminka Mrdjanović, Aleksandra Jovanović Galović, Nebojša Kladar, Biljana Božin, Vladimir Jurišić, Gordana Bogdanović   +6 more
openalex   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Reply to comment by R. C. Moore and M. T. Rietveld on “Geometric modulation: A more effective method of steerable ELF/VLF wave generation with continuous HF heating of the lower ionosphere” [PDF]

, 2009
M. B. Cohen, U. S. Inan, Mark Gołkowski
openalex   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Adduct formed by chromium trioxide and zwitterionic quinolinic acid

Open Chemistry, 2010
Sundberg Markku, Uggla Rolf, Sillanpää Reijo, Zborowski Krzysztof, Sánchez-González Angel, Matikainen Jorma, Kaltia Seppo, Hase Tapio   +7 more
doaj   +1 more source

Comparison of Extremely Low Frequency Electromagnetic Waves in Different Parts of Residential Houses in Yazd City [PDF]

Journal of Environmental Health and Sustainable Development
Introduction: Extremely low frequency (ELF) waves are less than 300 Hz. Electrical devices with city electricity are one of the most important sources of generating ELF waves.
Negar Zare Banadkooki, Rohollah Fallah Madvari, Sara Jambarsang, Fahimeh Teimouri, Javad Rabi Haghighi   +4 more
doaj  

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source