Results 91 to 100 of about 33,113 (293)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Moral anger, but not moral disgust, responds to intentionality [PDF]

, 2011
We propose that, when people judge moral situations, anger responds to the contextual cues of harm and intentionality. On the other hand, disgust responds uniquely to whether or not a bodily norm violation has occurred; its apparent response to harm and ...
Giner-Sorolla, Roger, Russell, Pascale S.   +1 more
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

ENHANCEMENT OF ANTIOXIDANT ABILITIES AND THE LIPOXYGENASE AND XANTHINE OXIDASE INHIBITORY ACTIVITY OF BROCCOLI SPROUTS BY BIOTIC ELICITORS

Acta Scientiarum Polonorum: Hortorum Cultus, 2012
Saccharomyces cerevisiae (SC) and Salix daphnoides bark (SD) water extracts were used for improving health-beneficial capacity of broccoli sprouts. The SC dilutions tested were 0.1, 0.5 and 1% (w/v), the SD concentration was 1% (w/v).
Urszula Gawlik-Dziki, Michał Świeca, Danuta Sugier   +2 more
doaj  

Grape marc extract causes early perception events, defence reactions and hypersensitive response in cultured tobacco cells [PDF]

, 2014
Plant Physiol. Biochem. ISI Document Delivery No.: AE5EJ Times Cited: 0 Cited Reference Count: 34 Benouaret, R. Goujon, E. Goupil, P. FUI: Fonds Unique Interministeriel We thank Celine Sac for help with the tobacco cell cultures and laboratory assistance.
Benouaret, Razik, Goujon, Eric, Goupil, Pascale   +2 more
core   +4 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Synergistic use of iron nanofertilizers and biotic elicitors to induce defensive volatile organic compound emissions from Brassica napus [PDF]

Journal of Plant Protection Research
In light of the increasing world’s population and progressing climate changes, novel visions for agricultural practices are needed. In recent years nanofertilizers and elicitors have been investigated as methods to provide improved crop yield and quality.
Dariusz Piesik, Anna Wenda-Piesik, Jacek Łyczko, Grzegorz Lemańczyk, Jan Bocianowski, Magdalena Piesik   +5 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Extracellular Fragmented Self-DNA Displays Biostimulation of Lettuce in Soilless Culture

Horticulturae
Research is advancing regarding techniques that are based on natural products developed using the plants. Extracellular DNA (eDNA) is a potential alternative that can be used as active material in agronomy. The objective of this study was to evaluate the
Tatiana P. L. Cunha-Chiamolera, Miguel Urrestarazu, Ireri A. Carbajal-Valenzuela, José Barroso Ramos, Raúl Ortega, Isabel Miralles, Ramón Gerardo Guevara-González   +6 more
doaj   +1 more source