Results 81 to 90 of about 33,113 (293)

Characterization of peroxidase and catalase genes in defense mechanisms of Physcomitrella patens [PDF]

, 2019
Systemic acquired resistance (SAR) and the hypersensitive response (HR) are two important induced defense mechanisms in plants. SAR is the development of an enhanced resistance to a pathogen due to a prior encounter.
Ciulla, Lauren
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of native Trichoderma viride and Pseudomonas fluorescens on the development of Cuscuta campestris on chickpea, Cicer arietinum [PDF]

, 2014
Cuscuta campestris Yuncker is a serious parasite on several leguminous crops including chickpea in India. Chickpea is an important pulse crop in India and severe incidence of Cuscuta may result in yield loss of about 85.7%.
Aditi, P., Gharde, Y., Kannan, C., Kumar, B.   +3 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tropospheric ozone as a fungal elicitor

Journal of Biosciences, 2009
Tropospheric ozone has been proven to trigger biochemical plant responses that are similar to the ones induced by an attack of fungal pathogens,i.e. it resembles fungal elicitors.This suggests that ozone can represent a valid tool for the study of stress responses and induction of resistance to pathogens.
openaire   +2 more sources

Fungal cellulase is an elicitor but its enzymatic activity is not required for its elicitor activity [PDF]

Molecular Plant Pathology, 2014
Summary Plant‐pathogenic fungi produce cellulases. However, little information is available on cellulase as an elicitor in plant–pathogen interactions. Here, an endocellulase ( EG 1) was isolated from R ...
Yanan, Ma, Chao, Han, Jinyin, Chen, Haiyun, Li, Kun, He, Aixin, Liu, Duochuan, Li   +6 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Disassociation Intuitions [PDF]

, 2018
We should disassociate ourselves from wrongdoing. If Hobby Lobby is against LGBTQ rights, we shouldn’t shop there. If Old Navy sources their clothing from sweatshops, we shouldn’t buy them.
Fischer, Bob, Wiegman, Isaac
core  

Molecular effects of resistance elicitors from biological origin and their potential for crop protection [PDF]

, 2014
Plants contain a sophisticated innate immune network to prevent pathogenic microbes from gaining access to nutrients and from colonising internal structures.
Altschul, Amelot, Armstrong, Ashburner, Aziz, Beckers, Berrocal-Lobo, Bethke, Birch, Bishop, Bittel, Bittelli, Block, Boch, Bonnet, Bos, Bourque, Bozkurt, Brunner, Brutus, Bülow, Bülow, Chen, Chen, Chinchilla, Chini, Cluzet, Coll, Conrath, Conrath, Copping, Craigie, Daayf, Daayf, Danna, Day, de Jonge, de Jonge, de Oliveira, De Vleesschauwer, Dehne, Desaki, Deslandes, Djamei, Djonoviç, Doehlemann, Dow, Du, El Ghaouth, El Hadrami, Erbs, Eshraghi, Eulgem, Falcón-Rodríguez, Felix, Ferrari, Flors, Fu, Galletti, Garcion, Gaulin, Gerber, Gilroy, Gomez-Gomez, Goupil, Grant, Guo, Hahn, Heese, Hein, Henriquez, Henry, Huang, Huffaker, Igarashi, Jaskiewicz, Jaulneau, Jelenska, Jeworutzki, Jin, Jones, Kamoun, Kano, Kawaguchi, Kawamura, Khan, Khatib, Khokon, Kim, King, Kishimoto, Knoth, Kohler, Kombrink, Konstantinidou-Doltsinis, Koschmann, Kulye, Kunze, Lacombe, Lamesch, Laquitaine, Lee, Li, Libault, Liebrand, Liu, Liu, Livaja, Livaja, Lochman, Maffei, Mateos, Mazzotta, McLellan, Medeiros, Mercier, Milling, Mizoguchi, Mukhtar, Newman, Newton, Nguyen, Nürnberger, Parker, Pastor, Pedersen, Peng, Po-Wen, Povero, Qiao, Qiu, Qutob, Rafiqi, Randoux, Reglinski, Reglinski, Reglinski, Ron, Sangha, Schornack, Schönbeck, Schönbeck, Shimizu, Shinya, Shinya, Shoresh, Steiner, Suzuki, Takahashi, Takken, Tanaka, Thomas, Umemura, Underwood, van den Burg, van Hulten, Vatsa, Vera, Viterbo, Walters, Walters, Walters, Wan, Wang, Wang, Wang, Wang, Wei, Xu, Yang, Yang, Zhang, Zhang, Zhang, Zhang, Zhang, Zheng, Zipfel, Zipfel   +178 more
core   +4 more sources