Results 101 to 110 of about 120,874 (227)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Heterointerface‐Functionalized Photoelectric Response of Metal‐Oxide Schottky Photodiode for Intelligent Fire Detection

Advanced Science, EarlyView.
A heterointerface‐functionalized Schottky photodiode (HF‐SPD) is developed to explore the photoelectric capabilities of low‐temperature oxide semiconductors. Besides the remarkable UV detection capability, the bias‐tunable photo response endows HF‐SPD with the unique wavelength selectivity.
Yuyang Cai, Zhiwei Zheng, Zhiwu Zhong, Yuhan Zhang, Tengyan Huang, Yucheng Cao, Dawei Zheng, Yen Hung Lin, Fion Sze Yan Yeung, Kuan‐Chang Chang, Jie Chen, Hoi Sing Kwok, Lei LU, Yufeng Jin   +13 more
wiley   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Surface Graphitized Mesoporous Carbon Surpasses the Conductivity–Porosity Trade‐Off

Advanced Science, EarlyView.
Electrochemical cathodic polarization in molten CaCl2‐NaCl converts mesoporous carbon (MC) into surface‐graphitized mesoporous graphite, simultaneously increasing surface area (397–867 m2/g) and electrical conductivity (26–450 S/cm) without mass loss.
Juntian Fan, Yating Yuan, Tao Wang, Huimin Luo, Fan Wang, Qingju Wang, Shannon M. Mahurin, Bishnu P. Thapaliya, Lilin He, Jue Liu, Nikolaos Samartzis, Zhenzhen Yang, Sheng Dai   +12 more
wiley   +1 more source

Decoding Proton‐Coupled Electron Transfer Mechanism of Nicotine for Multi‐Scenario Portable Electrochemical Sensing

Advanced Science, EarlyView.
A key challenge in nicotine electroanalysis is the unresolved complexity of its interface process, which directly determines sensor metrics. Herein, the proton‐coupled electron transfer mechanism of nicotine is decoded for multi‐scenario portable electrochemical sensing.
Yi Peng, Qinyi Cao, Qianyu Shen, Yuhang Zhang, Shiyu Hu, Hongdou Yi, Qian Liu, Lihui Ou, Qiang Li, Zhaohong Su   +9 more
wiley   +1 more source

Non‐Equilibrium Synthesis Methods to Create Metastable and High‐Entropy Nanomaterials

Advanced Science, EarlyView.
ABSTRACT Stabilizing multiple elements within a single phase enables the creation of advanced materials with exceptional properties arising from their complex composition. However, under equilibrium conditions, the Hume–Rothery rules impose strict limitations on solid‐state miscibility, restricting combinations of elements with mismatched crystal ...
Shuo Liu, Chaochao Dun, Jeffrey J. Urban, Mark T. Swihart   +3 more
wiley   +1 more source

Enhanced Photocatalytic CO2 Reduction Performance by External Electric Field‐Driven Charge Separation on Interdigitated Micro‐Spacing Structure

Advanced Science, EarlyView.
An external electric field‐enhanced photocatalytic system is developed using interdigitated electrodes with 100 µm spacing to overcome the liquid‐phase limitations of traditional PEC. The induced high‐intensity electric field effectively drives the directional migration of charge carriers under low voltage. This strategy significantly suppresses charge
Xidan Tang, Zhenyu Yu, Jie Liang, Xiaoguang Wang, Qin Shi, Honghui Pan, Xixiang Liu, Pengyi Tang   +7 more
wiley   +1 more source

Halogen‐Bond Coupled Halogenated‐π‐Conjugation Enables Giant Birefringence in Hydrogen‐Bonded Organic Frameworks

Advanced Science, EarlyView.
The perfect crystal packing achieved via the halogen‐bond (XB) coupled halogenated‐π‐conjugation strategy effectively induces an ultrahigh birefringence (Δn = 0.97), which exhibits promising potential in polarization control and phase modulation.
Miao‐Bin Xu, Yun‐Xia Hu, Ming‐Chang Wang, Jia‐Jia Li, Jia‐Min Lian, Jin Chen, Ke‐Zhao Du   +6 more
wiley   +1 more source

Ambient Hydrocarbonylation of Olefins Enabled by Visible‐Light

Advanced Science, EarlyView.
A novel photo‐induced methodology for hydrocarbonylation has been established, resolving the inherent conflicts between competitive olefin and CO insertion in traditional methods that necessitate harsh conditions. Accordingly, an efficient and versatile hydrocarbonylation of olefins enabled by visible‐light irradiation under ambient conditions has been
Hongchi Liu, Tianze Zhang, Hanmin Huang
wiley   +1 more source