Results 111 to 120 of about 127,505,457 (284)

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Solvent‐Free Synthesis of Ultrabright Carbon Dots With Near‐Unity Quantum Yield for High‐Performance Light‐Emitting Diodes

Advanced Science, EarlyView.
A rational, solvent‐free synthesis utilizing 2,6‐diaminonaphthalene produces ultrabright green‐emissive carbon dots. Regulated by a self‐limiting oxidative capping mechanism, excitons undergo ultrafast intra‐particle funneling from the nitrogen‐doped carbon core to emissive surface traps.
Hyeonjin Park, Su Hwan Lee, Sejeong Seo, Soye Park, Soo min Ji, Hyunda Jo, Sehyeon Park, Young‐Hoon Kim, Woosung Kwon   +8 more
wiley   +1 more source

Complexity and Contradiction at Fifty

, 2019
Complexity and Contradiction in Architecture is the founding text of postmodernism in architecture. First published in 1966, Robert Venturi’s Complexity and Contradiction in Architecture, widely considered the foundational text of postmodernism, has ...
Pier Paolo Tamburelli
core  

Literal Chunk Contradiction and Clause Regular Contradiction in Propositional Logic [PDF]

The resolution principle is a concise,reliable,and complete inference rule in automatic reasoning.The contradiction sepa-ration-based dynamic multi-clause synergized automated deduction is an extension of the resolution principle,and the contradiction is
WANG Chenglong, HE Xingxing, ZANG Hui, LI Yingfang, WANG Danchen, LI Tianrui
core   +1 more source

Two‐Dimensional Flash Memory: Materials, Interfaces, and Storage–Computing Convergence

Advanced Science, EarlyView.
We systematically summarize recent advances in 2D flash memory, highlighting how interface and material engineering can overcome the conventional trade‐offs among speed, power consumption, and reliability in silicon‐based flash, and outlining its potential for high‐performance memory and in‐memory computing applications.
Zhiyuan Wang, Fanyi Meng, Fanying Meng, Shida Huo, Junxi Xu, Yaohui Wang, Yuexuan Ma, Yuan Xie, Xiaodong Hu, Caofeng Pan, Enxiu Wu   +10 more
wiley   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Contradiction-Aware Strategy Synthesis in Agent Skills via Loop Engineering: A Controlled Empirical Comparison with Conventional Search

We present a controlled empirical comparison between a conventional web-search-based schol-arship search and a structured, AI-agent “skill” (/scholarship-strategy-report) that rendersa consulting-grade strategy report. Using a five-stage loop-engineering
Piyush Omanwar (24379973)
core   +1 more source

Research Progress, System Construction and Prospect of Urban Recreational Green Space Layout in Response to Human-Oriented Demands in China

Fengjing Yuanlin
ObjectiveChina’s urbanization has entered a new phase of connotative development. The concept of “People’s City” is driving the transformation of urban recreational green space (URGS) planning towards “human-oriented demands”.
Zhentao YU, Nan TAO
doaj   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Cr1/4NbSe2‐Single Crystal Growth and Evolution of Antiferromagnetic Correlated States

Advanced Science, EarlyView.
High‐quality single crystals Cr1/4NbSe2 were synthesized and comprehensively characterized for the first time. Advanced structural, electronic, and magnetic measurements uncover a correlated antiferromagnetic state, resolving longstanding inconsistencies regarding magnetic behavior derived from earlier polycrystal studies.
Nour Abdelrahman, Bastian Rubrecht, Matheus Felipe de Souza Barbosa, Mahdi Behnami, Dmitriy Efremov, Daniel Wolf, Martin Valldor, Alexey A. Popov, Stanislav M. Avdoshenko, Marco Naumann, Martin Knupfer, Vladislav Kataev, Alexey Alfonsov, Anja U. B. Wolter, Michael Mertig, Bernd Büchner, Silke Hampel   +16 more
wiley   +1 more source