Results 41 to 50 of about 942,536 (317)

Malaria elimination and the need for intensive inter-country cooperation: a critical evaluation of regional technical co-operation in Southern Africa

Malaria Journal
Background Malaria elimination requires closely co-ordinated action between neighbouring countries. In Southern Africa several countries have reduced malaria to low levels, but the goal of elimination has eluded them thus far.
Chadwick H. Sikaala, Bongani Dlamini, Alphart Lungu, Phelele Fakudze, Mukosha Chisenga, Chishala Lukwesa Siame, Nyasha Mwendera, Dumisani Shaba, John M. Chimumbwa, Immo Kleinschmidt   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Coping with COVID-19: a prospective cohort study on young Australians' anxiety and depression symptoms from 2020–2021

Archives of Public Health
Background Studies have shown that the coronavirus (COVID-19) pandemic negatively impacted the mental health of young Australians. However, there is limited longitudinal research exploring how individual factors and COVID-19 related public-health ...
Ana Orozco, Alexander Thomas, Michelle Raggatt, Nick Scott, Sarah Eddy, Caitlin Douglass, Cassandra J. C. Wright, Tim Spelman, Megan S. C. Lim   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Elimination by Substitution

Journal of Symbolic Computation
Let $K$ be a field and $P=K[x_1,\dots,x_n]$. The technique of elimination by substitution is based on discovering a coherently $Z=(z_1,\dots,z_s)$-separating tuple of polynomials $(f_1,\dots,f_s)$ in an ideal $I$, i.e., on finding polynomials such that $f_i = z_i - h_i$ with $h_i \in K[X \setminus Z]$.
Martin Kreuzer, Lorenzo Robbiano
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Are we nearly there yet? Coverage and compliance of mass drug administration for lymphatic filariasis elimination. [PDF]

, 2015
Lymphatic filariasis has been targeted for elimination by 2020, and a threshold of 65% coverage of mass drug administration (MDA) has been adopted by the Global Programme to Eliminate Lymphatic Filariasis (GPELF).
Alexander, Neal DE
core   +1 more source

Practical solutions to resolve social barriers to hepatitis C treatment initiation among people who inject drugs: a qualitative study

Harm Reduction Journal
Background We aimed to identify motivators for people who inject drugs to pursue treatment for hepatitis C virus (HCV) infection and uncover opportunities that could make treatment more appealing.
Phyo Aung, Margaret Hellard, Paul Dietze, Bek Petrovic, Peter Higgs, Mark Stoové   +5 more
doaj   +1 more source

Coverage, determinants of use and repurposing of long-lasting insecticidal nets two years after a mass distribution in Lihir Islands, Papua New Guinea: a cross-sectional study

Malaria Journal, 2021
Background Universal coverage with long-lasting insecticidal nets (LLINs) is an essential component of malaria control programmes. Three-yearly mass distribution of LLINs in Papua New Guinea (PNG) has been successful in reducing infection transmission ...
Pere Millat-Martínez, Rebecca Gabong, Núria Balanza, Sakaia Luana, Sergi Sanz, Silvia Raulo, Arthur Elizah, Chilaka Wali, Benjamin Paivu, Julian Dalmas, Samson Tabie, Stephan Karl, Moses Laman, William Pomat, Oriol Mitjà, Bàrbara Baro, Quique Bassat   +16 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source