Results 51 to 60 of about 2,185,452 (297)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Practical solutions to resolve social barriers to hepatitis C treatment initiation among people who inject drugs: a qualitative study

Harm Reduction Journal
Background We aimed to identify motivators for people who inject drugs to pursue treatment for hepatitis C virus (HCV) infection and uncover opportunities that could make treatment more appealing.
Phyo Aung, Margaret Hellard, Paul Dietze, Bek Petrovic, Peter Higgs, Mark Stoové   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Health systems readiness and quality of inpatient malaria case-management in Kano State, Nigeria

Malaria Journal, 2020
Background Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine to artesunate.
Abiodun A. Ojo, Kolawole Maxwell, Olusola Oresanya, Justice Adaji, Prudence Hamade, James K. Tibenderana, Saddiq S. Abubakar, Bala M. Audu, Ahmad Njidda, Aishatu B. Gubio, Robert W. Snow, Dejan Zurovac   +11 more
doaj   +1 more source

On Computing the Elimination Ideal Using Resultants with Applications to Gr\"obner Bases [PDF]

, 2015
Resultants and Gr\"obner bases are crucial tools in studying polynomial elimination theory. We investigate relations between the variety of the resultant of two polynomials and the variety of the ideal they generate.
Gallet, Matteo, Rahkooy, Hamid, Zafeirakopoulos, Zafeirakis   +2 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Edge Elimination in TSP Instances

, 2014
The Traveling Salesman Problem is one of the best studied NP-hard problems in combinatorial optimization. Powerful methods have been developed over the last 60 years to find optimum solutions to large TSP instances.
DL Applegate, G Dantzig, K Helsgaun, M Held, MR Garey, R Jonker   +5 more
core   +1 more source

Tensor decomposition and homotopy continuation [PDF]

, 2016
A computationally challenging classical elimination theory problem is to compute polynomials which vanish on the set of tensors of a given rank. By moving away from computing polynomials via elimination theory to computing pseudowitness sets via ...
Bernardi, Alessandra, Daleo, Noah S., Hauenstein, Jonathan D., Mourrain, Bernard   +3 more
core   +4 more sources