Results 71 to 80 of about 942,536 (317)

malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication [PDF]

, 2017
Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control ...
malERA Refresh Consultative Panel on Tools for Malaria Eliminati, malERA Refresh Consultative Panel on Tools for Malaria Elimination, Elimination, The malERA Refresh Consultative Panel on Tools for Malaria, The malERA Refresh Consultative Panel on Tools for Malaria Elimination (5064680)   +3 more
core   +1 more source

Understanding Long COVID Among Young People in Victoria, Australia: Prevalence, Impact, and Associated Factors

Public Health Challenges
Introduction Long COVID is a significant public health concern. This study aimed to identify the prevalence, impact, and factors associated with long COVID among young people in Victoria, Australia.
Robin Engelberts, Caitlin H. Douglass, Ana Orozco, Sarah Eddy, Anna Lee Wilkinson, Aimée Altermatt, Suzanne van denToren, Megan S. C. Lim   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Towards a science of rabies elimination [PDF]

, 2013
Wenwu Yin and co-workers conducted a systematic review on challenges and needs to eliminate rabies in China (Yin et al., 2013 in this journal). Their analysis shows that there is considerable overrepresentation of laboratory and basic epidemiology ...
Zinsstag, Jakob
core   +1 more source

Health equity for young Black sexually minoritized men through their eyes: a qualitative study

BMC Public Health
Background Young Black sexually minoritized men (YBSMM) are a key population for Ending the HIV Epidemic though their care engagement is limited due to inequities shaped by social determinants of health.
Jordan Victorian, Mayra Malagon, Alicia Dawdani, Marie Grace Giramahoro, John A. Schneider, Alida Bouris, Jade Pagkas-Bather   +6 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Insecticide-treated nets mass distribution campaign: benefits and lessons in Zambia

Malaria Journal, 2018
Background Zambia was an early adopter of insecticide-treated nets strategy in 2001, and policy for mass distribution with long-lasting insecticidal nets (LLINs) in 2005. Since then, the country has implemented mass distribution supplemented with routine
Freddie Masaninga, Nawa Mukumbuta, Ketty Ndhlovu, Busiku Hamainza, Pauline Wamulume, Emmanuel Chanda, John Banda, Mercy Mwanza-Ingwe, John M. Miller, Birkinesh Ameneshewa, Abraham Mnzava, Elizabeth Kawesha-Chizema   +11 more
doaj   +1 more source

The use of spatial and genetic tools to assess Plasmodium falciparum transmission in Lusaka, Zambia between 2011 and 2015

Malaria Journal, 2020
Background Zambia has set itself the ambitious target of eliminating malaria by 2021. To continue tracking transmission to zero, new interventions, tools and approaches are required.
Daniel J. Bridges, Sandra Chishimba, Mulenga Mwenda, Anna M. Winters, Erik Slawsky, Brenda Mambwe, Conceptor Mulube, Kelly M. Searle, Aves Hakalima, Roy Mwenechanya, David A. Larsen   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source