Results 61 to 70 of about 2,185,452 (297)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aminomethanol water elimination: Theoretical examination [PDF]

, 2005
The mechanism for the formation of hexamethylenetetraamine predicts the formation of aminomethanol from the addition of ammonia to formaldehyde. This molecule subsequently undergoes unimolecular decomposition to form methanimine and water.
Blake, Geoffrey A., Feldmann, Michael T., Goddard, William A., III, Kent, David R., IV, Widicus, Susanna L.   +4 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mild structure, low pressure: how might we increase young people’s social connection in the COVID-19-era

International Journal of Adolescence and Youth
This study aimed to understand how COVID-19 affected social connection, barriers to connection, and generated ideas for creating pro-connection activities and spaces.
Megan S. C. Lim, Angela C. Davis, Callan Rowe, Caitlin H. Douglass   +3 more
doaj   +1 more source

A semi-field evaluation in Thailand of the use of human landing catches (HLC) versus human-baited double net trap (HDN) for assessing the impact of a volatile pyrethroid spatial repellent and pyrethroid-treated clothing on Anopheles minimus landing

Malaria Journal, 2023
Background The mosquito landing rate measured by human landing catches (HLC) is the conventional endpoint used to evaluate the impact of vector control interventions on human-vector exposure.
Élodie A. Vajda, Manop Saeung, Amanda Ross, David J. McIver, Allison Tatarsky, Sarah J. Moore, Neil F. Lobo, Theeraphap Chareonviriyaphap   +7 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Costing analysis of a Queensland community corrections hepatitis C screening program

BMC Health Services Research
Background People involved with the criminal justice system typically have lower healthcare engagement and higher risk of hepatitis C virus (HCV) infection than the general population. Interventions run at community corrections centres have the potential
Kelly Maynard, Farah Houdroge, Rachael Thompson, Anna L. Hawkes, Alisa Pedrana, Jacqueline A. Richmond, Nick Scott   +6 more
doaj   +1 more source

Cut-elimination for the modal Grzegorczyk logic via non-well-founded proofs

, 2017
We present a sequent calculus for the modal Grzegorczyk logic Grz allowing non-well-founded proofs and obtain the cut-elimination theorem for it by constructing a continuous cut-elimination mapping acting on these proofs.Comment: WOLLIC'17, 12 pages, 1 ...
A Avron, DS Shamkanov, LL Maksimova, LL Maksimova, M Borga, R Dyckhoff   +5 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Quality of inpatient test-and-treat malaria case-management in public and private hospitals in Kano State, Nigeria

Malaria Journal
Background Compliance with evidence-based treatment guidelines, supported by quality-assured parasitological diagnosis, is the mainstay of malaria case-management in Nigeria.
Dawit Getachew, Nnenna Ogbulafor, Emmanuel Shekarau, Babangida Musa, Abdullahi Yusuf, Safiyanu Haruna, Oladipo O. Oladosu, Olusola Oresanya, Kolawole Maxwell, Dejan Zurovac   +9 more
doaj   +1 more source