Results 21 to 30 of about 443 (222)

Three-Dimensional Temperature Distribution Reconstruction via an Ellipsoidal Reflector: Algorithm Development and Numerical Validation

Applied Sciences
Accurate measurement of three-dimensional flame temperature distribution is crucial for combustion diagnosis. Traditional optical methods rely on observation windows or multi-camera arrays, which can be difficult to deploy in environments with restricted
Yaofang Zhang, Shi Liu
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

OPTICAL FEEDBACK BASED ON THE PHOTOMETRYBY ELLIPSOIDAL REFLECTOR IN BIONIC FINGERS APPLICATION [PDF]

KPI Science News, 2019
Background. The investigation focus is the specificity of effective recognition of surface types during the interaction between finger prosthesis and manipulation objects, and organization of optical feedback system in the control module of bionic limb.Objective.
Vonsevych, Kostiantyn P., Bezuglyi, Mikhail O., Prytula, Olha A.   +2 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Flux profile optimisation of a high-flux solar simulator using the trust-region reflective method

International Journal of Sustainable Energy
In multi-lamp, high-flux solar simulators, the flux profile can be affected by the choice of lamp, reflector, and a variety of geometric design parameters, some of which can be altered after construction.
Mohammed Hamid Hussain, Justin Lapp
doaj   +1 more source

Grazing-incidence ellipsoidal reflector for longitudinally pumping short-wavelength lasers [PDF]

Optics Letters, 1987
We propose using a prolate ellipsoid for collecting and focusing soft-x-ray radiation from a laser-produced plasma to longitudinally pump short-wavelength lasers. Total collection efficiencies greater than 20% at 10 nm into gain regions with aspect ratios of 25 are possible.
J F, Young, J J, Macklin, S E, Harris
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Water-waves focusing by an elliptical reflector

Frontiers in Marine Science
Focusing water waves is a potential technology improving the power generation of wave energy converters. Two semi-ellipsoidal reflectors, including long-axis opening and short-axis opening, were adopted to investigate the water-wave focusing effects.
Yihan Wang
doaj   +1 more source