Results 41 to 50 of about 3,799 (260)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Computational Models of Material Interfaces for the Study of Extracorporeal Shock Wave Therapy
, 2012 Extracorporeal Shock Wave Therapy (ESWT) is a noninvasive treatment for a variety of musculoskeletal ailments. A shock wave is generated in water and then focused using an acoustic lens or reflector so the energy of the wave is concentrated in a small ...
Carter, Goodship, Mouzopoulos, Park
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Measuring CMB Polarization with ESA PLANCK SubMM-Wave Telescope [PDF]
, 2002 We analyze the polarization properties of the tilted off-axis dual-reflector submillimeter-wave telescope on the ESA PLANCK Surveyor designed for measuring the temperature anisotropies and polarization characteristics of the cosmic microwave background ...
Yurchenko, Vladimir
core +3 more sources
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Gregorian all-reflective optical system [PDF]
, 1977 An optical heterodyne receiver comprises a system of reflectors forming a folded Gregorian configuration for collecting a signal beam, and an optical detector located at the focus of the system.
King, W. L.
core +1 more source
New 60-cm Radio Survey Telescope with the Sideband-Separating SIS Receiver for the 200 GHz Band
, 2007 We have upgraded the 60-cm radio survey telescope located in Nobeyama, Japan. We developed a new waveguide-type sideband-separating SIS mixer for the telescope, which enables the simultaneous detection of distinct molecular emission lines both in the ...
Asayama, Shin'ichiro +12 more
core +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Performance of hemielliptic dielectric lens antennas with optimal edge illumination [PDF]
, 2009 The role of edge illumination in the performance of compact-size dielectric lens antennas (DLAs) is studied in accurate manner using a highly efficient algorithm based on the combination of the Muller boundary integral equations and the method of ...
Boriskin, A. V. +2 more
core +3 more sources
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source