Results 181 to 190 of about 2,703 (241)

Towards an ‘absolute’ timing of biostratigraphic and environmental phases from the Saalian late glacial to the Weichselian pleniglacial in central Europe—Insights from a lacustrine succession in Lichtenberg, northern Germany

Boreas, EarlyView.
Palynological records are central to the biostratigraphic subdivision of the Late Pleistocene in central Europe. Yet many interglacial and interstadial phases—such as the Eemian, Brörup and Odderade—remain only poorly constrained in time due to limited numerical dating.
Michael Hein, Thomas Kasper, Alexis Badai Samudra, Martin Theuerkauf, Markus Lothar Fischer, Neda Rahimzadeh, Maria Sekar Proborukmi, Sonja Rigterink, Agnieszka Gruszczyńska, Christian Zeeden, Simon Parfitt, David John Horne, Lucy Roberts, Dustin White, Lisa Brogmus, Hans von Suchodoletz, Tobias Lauer, Marcel Weiss, David Colin Tanner, Brigitte Urban   +19 more
wiley   +1 more source

Highest fusion performance without harmful edge energy bursts in tokamak. [PDF]

Nat Commun
Kim SK, Shousha R, Yang SM, Hu Q, Hahn SH, Jalalvand A, Park JK, Logan NC, Nelson AO, Na YS, Nazikian R, Wilcox R, Hong R, Rhodes T, Paz-Soldan C, Jeon YM, Kim MW, Ko WH, Lee JH, Battey A, Yu G, Bortolon A, Snipes J, Kolemen E.   +23 more
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, EarlyView.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Indirect comparison of epcoritamab vs chemoimmunotherapy, mosunetuzumab, or odronextamab in follicular lymphoma. [PDF]

Blood Adv
Danilov AV, Kambhampati Thiruvengadam S, Linton K, Cumings K, Chirikov V, Mutebi A, Bains Chawla S, Chhibber A, Rivas Navarro F, Marques Gonçalves F, Wang A, Ding Z, Alshreef A, Favaro E, Hoehn D, Sureda A.   +15 more
europepmc   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Piecemeal mitochondrial degradation in plants: a coordination between mitochondrial dynamics and mitophagosome formation. [PDF]

Autophagy
Ma J, Li C, Zhuang X.
europepmc   +1 more source

Longitudinal associations between school absence and mental health problems in adolescents in England: a retrospective cohort study using linked administrative data

Child and Adolescent Mental Health, EarlyView.
Background School absence is associated with mental health problems in adolescents, but most studies are cross‐sectional. Longitudinal studies where school absence precedes mental health problems are needed to infer whether school absence is associated with later mental health problems.
Sophie Epstein, Brian C.F. Ching, Alice Wickersham, Rina Dutta, Craig Morgan, Tamsin Ford, Richard D. Hayes, Johnny Downs   +7 more
wiley   +1 more source

Systematic review and meta-analysis: CAR-T vs bispecific antibody as third or later-line therapy for follicular lymphoma. [PDF]

Blood Cancer J
Ng LCK, Lee XH, Tan YC, Wong KL, Chow JCY, Ling VWT, Thong EWS, Chan EHL, Chan WL, Samuel M, Poon MLM.   +10 more
europepmc   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source