Results 231 to 240 of about 22,670 (283)

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Strength in diversity: unlocking the full potential of engineered living materials with multistrain collaboration. [PDF]

FEMS Microbiol Rev
Wilssens H, De Wannemaeker L, De Mey M.
europepmc   +1 more source

Addressing Bottlenecks to Achieve High‐Energy Sodium‐Ion Cells Using Tin Anodes

Advanced Energy Materials, Volume 16, Issue 17, 6 May 2026.
The challenges in coupling high voltage cathode with Sn‐alloying anode or in anode‐free cell, using glyme based electrolytes to realize high energy Na‐ion cells are reported. Surface protection strategy such as SnO coating on Sn or trapping the parasitic species from poisoning the anode, helps improving the cyclability, with ∼100% capacity retention ...
Parth Desai, Harshita Lohani, Wang Yu, François Ribot, Guillaume P. Laurent, Julien Bonefacino, Hervé Vezin, Dominique Foix, Carine Davoisne, Biao Zhang, Jean‐Marie Tarascon, Sathiya Mariyappan   +11 more
wiley   +1 more source

Ocular Syphilis With Unilateral Optic Papillitis and Outer Retinopathy Complicated by Diabetic Retinopathy. [PDF]

Cureus
Nonaka K, Takahashi Y, Hasegawa T, Iida T.   +3 more
europepmc   +1 more source

Integrated Assessment of Lipid Oxidation and Off‐Flavor Formation in Plant Protein Powders

Journal of the American Oil Chemists' Society, Volume 103, Issue 5, Page 371-386, May 2026.
Impact of residual lipids on oxylipin and off‐flavor formation in commercial plant proteins: A detailed analysis of precursor‐product relationships by GC‐FID, LC‐MS/MS, and GC‐MS. ABSTRACT The widespread adoption of plant proteins is hindered by their inherent off‐flavors, often linked to lipid oxidation products.
Fernanda Furlan Goncalves Dias, Wellington da Silva Oliveira, Stanislau Bogusz Junior, Ameer Y. Taha   +3 more
wiley   +1 more source

Structural Characterization, β‐Cyclodextrin Polymer Interaction, and Biological Assessment of the N‐Terminal Peptide from the RPD‐1 Big Defensin of Ruditapes p hilippinarum

Chemistry–Methods, Volume 6, Issue 5, May 2026.
Defensins are a large and ancient family of host–defence peptides present across vertebrates, invertebrates, and plants, where they play a crucial role in innate immunity. Among them, big defensins represent a structurally distinctive subfamily characterized by a hydrophobic N‐terminal domain and a cysteine‐rich C‐terminal β‐defensin‐like domain. Here,
Rita Turnaturi, Giuseppa Augello, Giuseppe Nocito, Marcello Tagliavia, Stefania Zimbone, Rosalia Pellitteri, Giuseppina Sabatino, Giuseppe Di Natale, Michele F. M. Sciacca, Milo Malanga, Antonino Mazzaglia, Melchiorre Cervello, Giuseppe Pappalardo   +12 more
wiley   +1 more source

Artificial Intelligence Empowers Solid-State Batteries for Material Screening and Performance Evaluation. [PDF]

Nanomicro Lett
Wang S, Liu J, Song X, Xu H, Gu Y, Fan J, Sun B, Yu L.   +7 more
europepmc   +1 more source

Adrenal Biomarkers of Stress in Transgender and Gender‐Diverse Adolescents

Developmental Psychobiology, Volume 68, Issue 3, May 2026.
ABSTRACT Transgender and gender diverse (TGD) adolescents are frequently exposed to minority stress, which may influence the hypothalamic–pituitary–adrenal (HPA) axis during critical developmental windows. Altered cortisol dynamics have been described in populations facing chronic stress, yet evidence in TGD youth is limited.
Simone Coslovich, Stefania Tonetto, Giulia Bragato, Gianluca Tamaro, Alice Fachin, Paolo Dalena, Lorenzo Zandonà, Antonella Fabretto, Egidio Barbi, Gianluca Tornese   +9 more
wiley   +1 more source

High-precision prediction method for mine deformation based on GNSS RTK and stacking ensemble learning. [PDF]

Sci Rep
Dong X, Ma R, Tian W, Zhao K, Zhong Z, Zhu J, Sun G, Xiang H.   +7 more
europepmc   +1 more source

Loss of ELM suppression with non-axisymmetric magnetic perturbations in ASDEX Upgrade helium plasmas

, 2023
Suttrop, W. ; https://orcid.org/0000-0003-0983-8881, Grover, O. ; https://orcid.org/0000-0002-7695-8050, Leuthold, N., Markl, M., McDermott, R. ; https://orcid.org/0000-0002-8958-8714, Kappatou, A. ; https://orcid.org/0000-0003-3341-1909, Ryan, D., Viezzer, E. ; https://orcid.org/0000-0001-6419-6848, Willensdorfer, M. ; https://orcid.org/0000-0002-1080-4200   +8 more
openaire   +1 more source