Results 31 to 40 of about 2,703 (241)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Application of non-integer-n RMP coil current waveform for ELM control in JA DEMO

Nuclear Fusion
We have studied the resonant magnetic perturbation (RMP) coil concept for edge localized mode (ELM) suppression in JA DEMO, a design concept of a steady-state tokamak demonstration reactor, based on the vacuum magnetic model.
S. Sugiyama, N. Aiba, Y. Suzuki, G. Matsunaga, Y. Nakamura, M. Furukawa, A. Ishizawa, Y. Sakamoto   +7 more
doaj   +1 more source

ELM Suppression by Boron Powder Injection and Comparison with Lithium Powder Injection on EAST

Journal of Fusion Energy, 2020
Type I edge-localized modes (ELMs) in the Experimental Advanced Superconducting Tokamak (EAST) were completely suppressed via boron powder injection into the X-point region of an upper-single null configuration over a wide range of operating conditions (2.8 
R. Maingi, J. S. Hu, Z. Sun, A. Diallo, K. Tritz, Y. Z. Qian, W. Xu, G. Z. Zuo, C. L. Li, M. Huang, Y. Ye, A. Bortolon, E. P. Gilson, R. Lunsford, D. K. Mansfield, A. Nagy, J. P. Qian, X. Z. Gong   +17 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence of n = 4 RMPs on pedestal structure and stability in EAST

Nuclear Fusion
Changes of pedestal structure and stability caused by n = 4 resonant magnetic perturbations (RMPs) for control of Edge Localized Modes (ELMs) in the EAST tokamak in a target plasma close to the ITER high- Q scenario are studied in this paper.
X.M. Wu, Y. Sun, Q. Ma, S. Gu, Y.F. Wang, K.N. Geng, X.X. Zhang, G.Q. Li, H. Sheng, T. Zhang, P.B. Snyder, Q. Zhang, J. qian, Y.Y. Li, B. Wan   +14 more
doaj   +1 more source

Density compensation with pellet fueling during ELM suppression with n = 4 RMP on metal-wall EAST tokamak

Nuclear Materials and Energy
Pellet injection is the most promising fueling method to achieve a deep particle deposition for future fusion reactors. On metal-wall EAST tokamak, a full density compensation has been achieved by the pellet fueling during ELM suppression with n = 4 RMP ...
Jilei Hou, Jie Zhang, Kaibo Nan, Liqing Xu, Guizhong Zuo, Manni Jia, Haotian Qiu, Guangle Lin, Yifei Jin, Jia Huang, Kaixuan Ye, Yue Chen, Jiansheng Hu   +12 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

MHD simulations of formation, sustainment and loss of quiescent H-mode in the all-tungsten ASDEX Upgrade

Nuclear Fusion, 2023
Periodic edge localized modes (ELMs) are the non-linear consequences of pressure-gradient-driven ballooning modes and current-driven peeling modes becoming unstable in the pedestal region of high confinement fusion plasmas.
Lorenz Meier, Matthias Hoelzl, Andres Cathey, Guido Huijsmans, Eleonora Viezzer, Mike Dunne, Jan van Dijk, Diego José Cruz Zabala, Karl Lackner, Sibylle Günter, the ASDEX Upgrade Team, the EUROfusion MST1 Team, the JOREK Team   +12 more
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source