Results 71 to 80 of about 22,670 (283)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Radiatively tamed divertor thermal loading in resonant magnetic perturbation (RMP)-driven, ELM-crash-suppressed plasmas

Nuclear Fusion
Edge-localized-modes (ELMs) suppression by non-axisymmetric resonant-magnetic-perturbation (RMP) provides the way to reach high performance fusion plasmas without a threatening level of transient heat fluxes to the walls of fusion devices.
Yongkyoon In, H.H. Lee, K. Kim, A. Loarte, I.H. Choi, J.Y. Heo, Y.S. Han, Wonho Choe, J. Hwang, H. Shin   +9 more
doaj   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Overview of the JET results in support to ITER [PDF]

, 2017
The 2014–2016 JET results are reviewed in the light of their significance for optimising the ITER research plan for the active and non-active operation. More than 60 h of plasma operation with ITER first wall materials successfully took place since its
Abduallev, S., Abhangi, M., Abreu, P., Afzal, M., Galdón-Quiroga, J., García Muñoz, Manuel, Litaudon, X., Viezzer, Eleonora   +7 more
core   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

The simulation of ELM control by the advanced divertor configuration in EAST

Nuclear Fusion
Edge localized modes (ELMs) are effectively suppressed in the ‘quasi-snowflake’ (QSF) divertor discharges, which has been observed in the Experimental Advanced Superconducting Tokamak (EAST).
Y.L. Li, T.Y. Xia, Z.P. Luo, Q.Z. Yu, S.F. Mao, B. Gui, X.X. He, H.M. Qi, P.C. Xie, M.Y. Ye, the EAST team   +10 more
doaj   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Active tungsten expulsion in ELM-absent H-mode plasmas via on-demand ELM triggering with lithium granule injection

Nuclear Fusion
Lithium granules gravitationally injected into the upper X -point region demonstrated on-demand edge-localized modes (ELM) triggering in otherwise ELM-suppressed H-mode plasmas on the Experimental Advanced Superconducting Tokamak. Sub-mm lithium granules
Z. Sun, R. Maingi, Y.X. Cheng, Y.Z. Qian, W. Xu, Z. Wang, L. Zhang, A. Bortolon, Y.M. Duan, M. Huang, Y.F. Wang, J. Huang, T. Zhang, L. Chen, W. Wang, J.H. Yang, Y.Y. Li, D.G. Wu, K. Jia, H.L. Zhao, Q. Zhang, K. Tritz, H.Q. Wang, R. Lunsford, A. Nagy, A. Diallo, G.Z. Zuo, X.Z. Gong, J.S. Hu, the EAST Team   +29 more
doaj   +1 more source

ELM triggering conditions for the integrated modeling of H-mode plasmas

, 2004
Recent advances in the integrated modeling of ELMy H-mode plasmas are presented. A model for the H-mode pedestal and for the triggering of ELMs predicts the height, width, and shape of the H-mode pedestal and the frequency and width of ELMs. Formation of
A. H. Kritz, A. Y. Pankin, A.H. Glasser, A.M. Dimits, A.Y. Pankin, D. D. Schnack, D. P. Brennan, G. Bateman, G. Bateman, G. Janeschitz, G. Pacher, G. W. Pacher, G.M. Staebler, H. D. Pacher, H. Wilson, H.R. Wilson, I. Voitsekhovitch, J. Weiland, J.-S. Lönnroth, J.W. Connor, K.H. Burrell, L.L. Lao, M. Sugihara, M.S. Chance, O. Sauter, O.V. Zolotukhin, P. B. Snyder, P.B. Snyder, P.B. Snyder, P.N. Guzdar, P.N. Guzdar, R.L. Miller, S. Hamaguchi, S. Kruger, T. Onjun, T. Onjun, T. Onjun, T.H. Osborne, T.S. Hahm, T.S. Hahm, W. Horton, W.A. Houlberg, Y.B. Kim   +42 more
core   +1 more source

Operational Space and Plasma Performance with an RMP-ELM Suppressed Edge

The operational space and global performance of plasmas with edge-localized modes (ELMs) suppressed by resonant magnetic perturbations (RMPs) are surveyed by comparing AUG, DIII-D, EAST, and KSTAR stationary operating points. RMP-ELM suppression is achieved over a range of plasma currents, toroidal fields, and RMP toroidal mode numbers.
Paz-Soldan, C., Gu, S., Leuthold, N., Lunia, P., Xie, P., Kim, M. W., Kim, S. K., Logan, N. C., Park, J. -K., Suttrop, W., Sun, Y., Weisberg, D. B., Willensdorfer, M., ASDEX-Upgrade, the, DIII-D, EAST, Teams, KSTAR   +16 more
openaire   +2 more sources