Results 71 to 80 of about 3,972 (282)

Elongation of Flare Ribbons [PDF]

The Astrophysical Journal, 2017
Abstract We present an analysis of the apparent elongation motion of flare ribbons along the polarity inversion line (PIL), as well as the shear of flare loops in several two-ribbon flares. Flare ribbons and loops spread along the PIL at a speed ranging from a few to a hundred km s−1.
Jiong Qiu, Dana W. Longcope, Paul A. Cassak, Eric R. Priest   +3 more
openaire   +4 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Purification and characterization of the human Elongator complex

, 2002
Human Elongator complex was purified to virtual homogeneity from HeLa cell extracts. The purified factor can exist in two forms: a six-subunit complex, holo-Elongator, which has histone acetyltransferase activity directed against histone H3 and H4, and a
Winkler, G.S., Krappmann, D., Tempst, P., Svejstrup, J.Q., Thomas, C.L., Marshall, N., Hawkes, N.A., Schiavo, G., Dahmus, M.E., Otero, G., Erdjument-Bromage, H., Scheidereit, C.   +11 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Meta-regulation of Arabidopsis Auxin Responses Depends on tRNA Maturation

Cell Reports, 2015
Polar transport of the phytohormone auxin throughout plants shapes morphogenesis and is subject to stringent and specific control. Here, we identify basic cellular activities connected to translational control of gene expression as sufficient to specify ...
Johannes Leitner, Katarzyna Retzer, Nenad Malenica, Rasa Bartkeviciute, Doris Lucyshyn, Gunilla Jäger, Barbara Korbei, Anders Byström, Christian Luschnig   +8 more
doaj   +1 more source

Structures and activities of the Elongator complex and Its cofactors

, 2017
Elongator is a highly conserved eukaryotic protein complex consisting of two sets of six Elp proteins, while homologues of its catalytic subunit Elp3 are found in all the kingdoms of life.
Bertrand Séraphin, Kolaj-Robin, Olga, Séraphin, Bertrand, Olga Kolaj-Robin   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Transcription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia [PDF]

, 2006
peer reviewedMutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics.
Jesper Q. Svejstrup, Isabelle Cornez, Cornez, Isabelle, Marie-Paule Merville, Alain Chariot, Catherine Creppe, Nicola Hawkes, Bours, Vincent, Slaugenhaupt, Susan A, Pierre Close, Susan A. Slaugenhaupt, Creppe, Catherine, Bernard Rogister, Charles A. Lambert, Lambert, Charles A, Svejstrup, Jesper Q, Hawkes, Nicola, Ulrich Siebenlist, Chariot, Alain, Rogister, Bernard, Close, Pierre, Vincent Bours, Siebenlist, Ulrich, Merville, Marie-Paule   +23 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Elongator, a conserved multitasking complex?

, 2010
Post-transcriptional modifications on transfer RNA (tRNA) molecules occur frequently but their implication on the translational regulation is only recently becoming fully appreciated.
De Groeve, Steven, Van Lijsebettens, Maria, Versées, Wim   +2 more
core   +1 more source