AtELP4 a subunit of the Elongator complex in Arabidopsis, mediates cell proliferation and dorsoventral polarity during leaf morphogenesis [PDF]
Frontiers in Plant Science, 2022 The Elongator complex in eukaryotes has conserved tRNA modification functions and contributes to various physiological processes such as transcriptional control, DNA replication and repair, and chromatin accessibility.
Sang Eun Jun +7 more
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Architecture of the yeast Elongator complex [PDF]
EMBO Reports, 2017 Abstract The highly conserved eukaryotic Elongator complex performs specific chemical modifications on wobble base uridines of tRNAs, which are essential for proteome stability and homeostasis. The complex is formed by six individual subunits (Elp1‐6) that are all equally important for its tRNA modification activity.
Karin Breunig +2 more
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Dimerization of elongator protein 1 is essential for Elongator complex assembly [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Elongator is a highly conserved multiprotein complex composed of six subunits elongator protein 1 (Elp1 to -6). Elongator has been associated with various cellular activities and has attracted clinical attention because of its role in certain neurodegenerative diseases.
Hao Zhou, Yuequan Shen, Zheng Wang
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Epigenomic Regulators Elongator Complex Subunit 2 and Methyltransferase 1 Differentially Condition the Spaceflight Response in Arabidopsis [PDF]
Frontiers in Plant Science, 2021 Background: Plants subjected to the novel environment of spaceflight show transcriptomic changes that resemble aspects of several terrestrial abiotic stress responses.
Anna-Lisa Paul +8 more
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Aspergillus fumigatus Elongator complex subunit 3 affects hyphal growth, adhesion and virulence through wobble uridine tRNA modification. [PDF]
PLoS Pathogens, 2022 The eukaryotic multisubunit Elongator complex has been shown to perform multiple functions in transcriptional elongation, histone acetylation and tRNA modification.
Yuanwei Zhang +4 more
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Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy [PDF]
Journal of Experimental & Clinical Cancer Research, 2021 Background Gallbladder cancer (GBC) is known for its high malignancy and multidrug resistance. Previously, we uncovered that impaired integrity and stability of the elongator complex leads to GBC chemotherapy resistance, but whether its restoration can ...
Sunwang Xu +7 more
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Cryo-EM structure of the fully assembled Elongator complex. [PDF]
Nucleic Acids Res, 2023 AbstractTransfer RNA (tRNA) molecules are essential to decode messenger RNA codons during protein synthesis. All known tRNAs are heavily modified at multiple positions through post-transcriptional addition of chemical groups. Modifications in the tRNA anticodons are directly influencing ribosome decoding and dynamics during translation elongation and ...
Jaciuk M +19 more
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The role of the Elongator complex in plants. [PDF]
Plant Signal Behav, 2011 The multi-subunit complex Elongator interacts with elongating RNA polymerase II (RNAPII) and is thought to facilitate transcription through histone acetylation. Elongator is conserved in eukaryotes, yet functions in diverse kingdom-specific processes.
DeFraia C, Mou Z.
europepmc +4 more sources
Journal of Integrative Agriculture, 2014 The Elongator complex is a multifunction protein complex which has been shown to be involved in transcriptional elongation, DNA replication and repair, tubulin and histone acetylation, gene silencing and tranfer RNA uridine modification.
Xu YAN +4 more
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Research progress of the Elongator complex in plant
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023 The Elongator complex consists of six subunits (ELP1-ELP6), where ELP1-ELP3 forms the core subcomplex and ELP4-ELP6 forms the auxiliary subcomplex. Deletion of any of the six subunits results in an almost identical phenotype, suggesting that all six ...
Ji XIANGZHUO +4 more
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