Cryo-EM structures of the human Elongator complex at work [PDF]
Nature CommunicationstRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble uridine bases (cm5U34) in eukaryotic tRNAs.
Nour-el-Hana Abbassi +16 more
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Molecular basis of tRNA recognition by the Elongator complex. [PDF]
Sci Adv, 2019 The catalytic Elp123 subcomplex of Elongator specifically recognizes and binds tRNAs in its active site.
Dauden MI +11 more
europepmc +8 more sources
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. [PDF]
PLoS Genetics, 2010 Although acetylated alpha-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate alpha-tubulin acetylation are, to date, largely unknown.
Jachen A Solinger +9 more
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Elongator is a microtubule polymerase selective for polyglutamylated tubulin [PDF]
The EMBO JournalElongator is a tRNA-modifying complex that regulates protein translation. Recently, a moonlighting function of Elongator has been identified in regulating the polarization of the microtubule cytoskeleton during asymmetric cell division. Elongator induces
Vicente J Planelles-Herrero +9 more
doaj +9 more sources
Purification and Characterization of the Human Elongator Complex [PDF]
Journal of Biological Chemistry, 2002 Human Elongator complex was purified to virtual homogeneity from HeLa cell extracts. The purified factor can exist in two forms: a six-subunit complex, holo-Elongator, which has histone acetyltransferase activity directed against histone H3 and H4, and a three-subunit core form, which does not have histone acetyltransferase activity despite containing ...
Nicola A, Hawkes +11 more
openaire +3 more sources
Elongator, a conserved multitasking complex? [PDF]
Molecular Microbiology, 2010 SummaryPost‐transcriptional modifications on transfer RNA (tRNA) molecules occur frequently but their implication on the translational regulation is only recently becoming fully appreciated. Several tRNA molecules in the eukaryotic cytoplasm carry a methoxycarbonylmethyl (mcm) or carbamoylmethyl (ncm) group on their wobble uridine to ensure the ...
Versees, Wim +2 more
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Elongator and the role of its subcomplexes in human diseases [PDF]
EMBO Molecular Medicine, 2022 The Elongator complex was initially identified in yeast, and a variety of distinct cellular functions have been assigned to the complex. In the last decade, several research groups focussed on dissecting its structure, tRNA modification activity and role
Monika Gaik +3 more
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Functional divergence of the two Elongator subcomplexes during neurodevelopment
EMBO Molecular Medicine, 2022 The highly conserved Elongator complex is a translational regulator that plays a critical role in neurodevelopment, neurological diseases, and brain tumors.
Monika Gaik +28 more
doaj +2 more sources
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development [PDF]
Nature CommunicationsPyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood.
Michela Di Michele +44 more
doaj +2 more sources
The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. [PDF]
PLoS Genetics, 2009 Histone chaperones CAF-1 and Asf1 function to deposit newly synthesized histones onto replicating DNA to promote nucleosome formation in a proliferating cell nuclear antigen (PCNA) dependent process.
Qing Li +5 more
doaj +2 more sources