Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. [PDF]
PLoS Genetics, 2009 Elongator is a six subunit protein complex, conserved from yeast to humans. Mutations in the human Elongator homologue, hELP1, are associated with the neurological disease familial dysautonomia.
Changchun Chen +2 more
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Epigenomes, 2020 First identified 20 years ago as an RNA polymerase II-associated putative histone acetyltransferase, the conserved Elongator complex has since been recognized as the central player of a complex, regulated, and biologically relevant epitranscriptomic ...
Damien Hermand
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Structure of the human RNA polymerase I elongation complex [PDF]
Cell Discovery, 2021 Abstract Eukaryotic RNA polymerase I (Pol I) transcribes ribosomal DNA and generates RNA for ribosome synthesis. Pol I accounts for the majority of cellular transcription activity and dysregulation of Pol I transcription leads to cancers and ribosomopathies. Despite extensive structural studies of yeast Pol I, structure of human Pol I
Yanhui Xu +5 more
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Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. [PDF]
PLoS Genetics, 2011 Elongator complex is required for formation of the side chains at position 5 of modified nucleosides 5-carbamoylmethyluridine (ncm⁵U₃₄), 5-methoxycarbonylmethyluridine (mcm⁵U₃₄), and 5-methoxycarbonylmethyl-2-thiouridine (mcm⁵s²U₃₄) at wobble position in
Changchun Chen +4 more
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Structural asymmetry in the eukaryotic Elongator complex [PDF]
FEBS Letters, 2017 Nucleoside modifications in tRNA anticodons regulate ribosome dynamics during translation elongation and, thereby, fine‐tune global protein synthesis rates. The highly conserved eukaryotic Elongator complex conducts specific C5‐substitutions in tRNA wobble base uridines.
Maria I. Dauden +3 more
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Elongator and its epigenetic role in plant development and responses to abiotic and biotic stresses
Frontiers in Plant Science, 2015 Elongator, a six-subunit protein complex, was initially isolated as an interactor of hyperphosphorylated RNA polymerase II in yeast, and was subsequently identified in animals and plants.
Yezhang eDing, Zhonglin eMou
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Building a super elongation complex for HIV [PDF]
eLife, 2013 A better understanding of the host cell protein complex that helps HIV replicate inside cells offers the possibility of new therapeutic targets.
Christopher P Hill, Wesley I Sundquist
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Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes. [PDF]
, 2011 Eukaryotic cells limit ribosomal DNA (rDNA) transcription by RNA polymerase I (RNAP-I) to maintain genome integrity. African trypanosomes present an excellent model for studies on RNAP-I regulation because they possess a bifunctional RNAP-I and because ...
Horn, David +4 more
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Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs. [PDF]
PLoS Genetics, 2013 The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display transcriptional defects. However, it has also been shown that Elongator
Jorge Fernández-Vázquez +10 more
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Toxins, 2017 Saccharomyces cerevisiae cells are killed by zymocin, a tRNase ribotoxin complex from Kluyveromyces lactis, which cleaves anticodons and inhibits protein synthesis.
Constance Mehlgarten +11 more
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