The Many Faces of Elongator in Neurodevelopment and Disease
Frontiers in Molecular Neuroscience, 2016 Development of the nervous system requires a variety of cellular activities, such as proliferation, migration, axonal outgrowth and guidance and synapse formation during the differentiation of neural precursors into mature neurons.
Marija Kojic, Brandon Wainwright
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Elp3 uses a conserved molecular tunnel to transport acetate between distant active sites and catalyze tRNA wobble base modification [PDF]
Nature CommunicationsThe radical SAM enzyme Elp3 and eukaryotic Elongator complex catalyze formation of a key intermediate transfer RNA (tRNA) modification, 5-carboxymethyluridine (cm5U), in the anticodons of tRNAs across all domains of life.
Evan P. Geissler +6 more
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Drosophila poly suggests a novel role for the Elongator complex in insulin receptor–target of rapamycin signalling [PDF]
Open Biology, 2012 Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalling is a highly conserved pathway that mediates this link.
Ekin Bolukbasi +6 more
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PP6 phosphatase and Elongator contribute to kinesin 5-dependent spindle assembly by controlling microtubule regulators levels. [PDF]
PLoS GeneticsEukaryotic chromosome segregation relies on the assembly of a bipolar machinery based on microtubules (MTs), named the mitotic spindle. Formation of the mitotic spindle follows a force balance mechanism that ensures the proper capture and separation of ...
Laura Marín +9 more
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The Elongator Complex Negatively Regulates Polarized Secretion [PDF]
, 2007 Intracellular transport is fundamental for eukaryotic life and the function of regulators of transport is evolutionarily conserved. Rab proteins are a family of key regulators of vesicle and organelle transport, which aid in cell proliferation and cell ...
Rahl, Peter
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CURLED LATER1 encoding the largest subunit of the Elongator complex has a unique role in leaf development and meristem function in rice [PDF]
Plant Journal, 2020 Hiro-Yuki Hirano +2 more
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ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels [PDF]
Plant Biotechnology JournalJinsheng Lai, Yang Zhijia, Tong Li
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A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex. [PDF]
Mol Microbiol, 2014 Elongator is a conserved, multi-protein complex discovered in Saccharomyces cerevisiae, loss of which confers a range of pleiotropic phenotypes. Elongator in higher eukaryotes is required for normal growth and development and a mutation in the largest ...
Di Santo R, Bandau S, Stark MJ.
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The Mediator complex and transcription elongation [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription.We provide a brief ...
Ronald C, Conaway, Joan Weliky, Conaway
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Elongator promotes neuritogenesis via regulation of tau stability through acly activity
Frontiers in Cell and Developmental Biology, 2022 The six subunits (Elp1 to Elp6) Elongator complex promotes specific uridine modifications in tRNA’s wobble site. Moreover, this complex has been indirectly involved in the regulation of α-tubulin acetylation in microtubules (MTs) via the stabilization of
Michal Shilian +4 more
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