Results 41 to 50 of about 5,172,961 (263)
The Arabidopsis ELP3/ELO3 and ELP4/ELO1 genes enhance disease resistance in Fragaria vesca L.
BMC Plant Biology, 2017 Background Plant immune response is associated with a large-scale transcriptional reprogramming, which is regulated by numerous transcription regulators such as the Elongator complex.
Katchen Julliany P. Silva +5 more
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Translation repression by an RNA polymerase elongation complex [PDF]
Molecular Microbiology, 2004 SummaryBacteriophage λ N and bacterial Nus proteins together with a unique site NUT in the leader of the early viral N gene transcript bind RNA polymerase (RNAP) and form a highly processive antitermination complex; N bound at NUT also represses N translation. In this study, we investigate whether N and NUT cause N translation repression as part of the
Helen R, Wilson +3 more
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Interference Footprinting Analysis of Telomerase Elongation Complexes [PDF]
Molecular and Cellular Biology, 2000 Telomerase is a reverse transcriptase that adds single-stranded telomeric repeats to the ends of linear eukaryotic chromosomes. It consists of an RNA molecule including a template sequence, a protein subunit containing reverse transcriptase motifs, and auxiliary proteins.
S, Benjamin, N, Baran, H, Manor
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The Elongation Factor Tu · Guanosine Tetraphosphate Complex [PDF]
European Journal of Biochemistry, 1981 The elongation factor Tu (EF‐Tu) isolated from Escherichia coli cells that have undergone the stringent response is predominantly complexed with guanosine 5′‐diphosphate 3′‐diphosphate. This complex can be separated by anion‐exchange chromatography from EF‐Tu · GDP‐ Unlike EF‐Tu complexed with guanosine 5′‐triphosphate 3′‐diphosphate, the complex with ...
A, Pingoud, W, Block
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The control of elongation by the yeast Ccr4–Not complex [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
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Frontiers in Cellular Neuroscience, 2017 The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective α-tubulin acetylation.
Sophie Laguesse +12 more
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Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype
Nature Communications, 2021 Subunits of the Elongator complex have been implicated in several nervous system pathologies. Here, the authors identify ELP2 variants in six patients with neurodevelopmental anomalies and show in mouse models that these variants impact protein stability
Marija Kojic +39 more
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Protection of antiterminator RNA by the transcript elongation complex [PDF]
Molecular Microbiology, 2007 SummaryNascent transcripts encoded by the putL and putR sites of phage HK022 bind the transcript elongation complex and suppress termination at downstream transcription terminators. We report here that the chemical stability of putL RNA is considerably greater than that of the typical Escherichia coli message because the elongation complex protects ...
Sieghild, Sloan +4 more
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Complexity of RNA polymerase II elongation dynamics [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012 Transcription of protein-coding genes by RNA polymerase II can be regulated at multiple points during the process of RNA synthesis, including initiation, elongation, and termination. In vivo data suggests that elongating polymerases exhibit heterogeneity throughout the gene body, suggestive of changes in elongation rate and/or pausing.
Murali, Palangat, Daniel R, Larson
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Germline Elongator mutations in Sonic Hedgehog medulloblastoma. [PDF]
, 2020 Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear.
Smith, Kyle S. +100 more
core +3 more sources