Results 1 to 10 of about 764 (211)
Transfer RNA Modification Enzymes from Thermophiles and Their Modified Nucleosides in tRNA
Microorganisms, 2018 To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes have been identified not only in thermophiles but also in mesophiles.
Hiroyuki Hori +6 more
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Detection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene TRDMT1 [PDF]
Archives Animal Breeding, 2021 The tRNA modification gene in eukaryotes is relatively conservative. As an important modification gene, the TRDMT1 gene plays an important role in maintaining tRNA structural maintenance and reducing mistranslation of protein translation by methylation ...
X. Yi +6 more
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Examining the Gm18 and mG Modification Positions in tRNA Sequences [PDF]
Genomics & Informatics, 2014 The tRNA structure contains conserved modifications that are responsible for its stability and are involved in the initiation and accuracy of the translation process. tRNA modification enzymes are prevalent in bacteria, archaea, and eukaryotes. tRNA Gm18
Mayavan Subramanian +2 more
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Computational and Structural Biotechnology Journal, 2023 Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always ...
Florian Pichot +9 more
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METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Clinical and Translational Medicine, 2021 Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood ...
Zhihang Chen +14 more
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Changes of the tRNA Modification Pattern during the Development of Dictyostelium discoideum
Non-Coding RNA, 2021 Dictyostelium discoideum is a social amoeba, which on starvation develops from a single-cell state to a multicellular fruiting body. This developmental process is accompanied by massive changes in gene expression, which also affect non-coding RNAs. Here,
Anne Hoffmann +5 more
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Bio-Protocol, 2019 Queuosine (Q) is a hypermodified base in the wobble anticodon position of tRNAs coding for the amino acids Tyr, His, Asn, and Asp. tRNA Q-modification is introduced by a queuine tRNA-ribosyltransferase (TGT) that replaces the guanine base at G34 at these
Zaneta Matuszek, Tao Pan
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Regulatory Factors for tRNA Modifications in Extreme- Thermophilic Bacterium Thermus thermophilus
Frontiers in Genetics, 2019 Thermus thermophilus is an extreme-thermophilic bacterium that can grow at a wide range of temperatures (50–83°C). To enable T. thermophilus to grow at high temperatures, several biomolecules including tRNA and tRNA modification enzymes show extreme heat-
Hiroyuki Hori
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Nature Communications, 2022 This paper develops a multiplex RNA-seq method that reports tRNA abundance, modification, charging, and fragmentation. Results show stress-induced regulation in translational elongation and association of modification and tRNA fragment biogenesis.
Christopher P. Watkins +4 more
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Impact of Pus1 Pseudouridine Synthase on Specific Decoding Events in Saccharomyces cerevisiae
Biomolecules, 2020 Pus1-dependent pseudouridylation occurs in many tRNAs and at multiple positions, yet the functional impact of this modification is incompletely understood.
Bahar Khonsari, Roland Klassen
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