Results 11 to 20 of about 764 (211)
Genome recoding by tRNA modifications [PDF]
Open Biology, 2016 RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. These modifications are particularly enriched in tRNAs where they can regulate not only global protein translation, but also protein translation at the ...
Francesca Tuorto, Frank Lyko
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m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum +3 more
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A primer on tRNAs, tRNA-m1A58 modification, and tRNA derivatives in T-cell activation
Frontiers in Cell and Developmental BiologyUpon antigen recognition, naive CD4+ T cells are activated, exiting quiescence to undergo rapid activation, clonal expansion, and differentiation into effector functions against pathogens.
Chuanxiang Zhao, Juxiang Shen
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Overview of tRNA Modifications in Chloroplasts [PDF]
Microorganisms, 2022 The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency.
Maxime Fages-Lartaud +1 more
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Extracurricular Functions of tRNA Modifications in Microorganisms [PDF]
Genes, 2020 Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality.
Ashley M. Edwards +2 more
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Probing the diversity and regulation of tRNA modifications [PDF]
Current Opinion in Microbiology, 2020 Transfer RNAs (tRNAs) are non-coding RNAs essential for protein synthesis. tRNAs are heavily decorated with a variety of post-transcriptional modifications (tRNA modifications). Recent methodological advances provide new tools for rapid profiling of tRNA modifications and have led to discoveries of novel modifications and their regulation.
Satoshi, Kimura +2 more
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Modification of tRNA as a regulatory device [PDF]
Molecular Microbiology, 1993 SummaryOur knowledge of the different biological roles of tRNA modification has increased considerably in recent years. Not only have we learned about how modified nucleosides affect the performance of tRNA in translation, but also how they influence regulation of intermediary metabolism, antibiotics production, gene expression in eukaryotic viruses ...
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Prediction of uridine modifications in tRNA sequences [PDF]
BMC Bioinformatics, 2014 In past number of methods have been developed for predicting post-translational modifications in proteins. In contrast, limited attempt has been made to understand post-transcriptional modifications. Recently it has been shown that tRNA modifications play direct role in the genome structure and codon usage.
Bharat Panwar, Gajendra P. S. Raghava
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tRNA wobble modifications and protein homeostasis [PDF]
Translation, 2016 tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring efficient protein synthesis, maintaining protein homeostasis, and helping cell adaptation and survival.
Ranjan, N., Rodnina, M.
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Biosynthesis and Degradation of Sulfur Modifications in tRNAs [PDF]
International Journal of Molecular Sciences, 2021 Various sulfur-containing biomolecules include iron–sulfur clusters that act as cofactors for enzymes, sulfur-containing vitamins such as thiamin, and sulfur-modified nucleosides in RNA, in addition to methionine and cysteine in proteins. Sulfur-containing nucleosides are post-transcriptionally introduced into tRNA molecules, where they ensure precise ...
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