Results 31 to 40 of about 764 (211)

Biosynthesis and function of tRNA modifications in Archaea

Current Opinion in Microbiology, 2011
tRNA modifications are important for decoding, translation accuracy, and structural integrity of tRNAs. Archaeal tRNAs contain at least 47 different tRNA modifications, some of them, including archaeosine, agmatidine, and mimG, are specific to the archaeal domain.
Microbiology and Cell Science Department, University of Florida, Gainesville, FL 32611, USA ( host institution ), Phillips, Gabriela, de Crécy-Lagard, Valérie   +2 more
openaire   +3 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Remodeling of tRNA modification in Trypanosoma cruzi life forms.

PLoS Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, infects millions of people in the Americas. This parasite undergoes drastic changes in its morphology and metabolism between infective and noninfective forms through global remodeling of its ...
Herbert Guimaraes de Sousa Silva, Janaina de Freitas Nascimento, Marilene Souza Braga, Ana Paula de Jesus Menezes, Ariel M Silber, Matthew K Waldor, Julia Pinheiro Chagas da Cunha, Satoshi Kimura   +7 more
doaj   +1 more source

Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape.

PLoS Genetics, 2020
Codon usage bias is a universal feature of all genomes and plays an important role in regulating protein expression levels. Modification of adenosine to inosine at the tRNA anticodon wobble position (I34) by adenosine deaminases (ADATs) is observed in ...
Xueliang Lyu, Qian Yang, Lin Li, Yunkun Dang, Zhipeng Zhou, She Chen, Yi Liu   +6 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants.

PLoS ONE, 2020
Posttranscriptional modification of tRNA is critical for efficient protein translation and proper cell growth, and defects in tRNA modifications are often associated with human disease.
Holly M Funk, Ruoxia Zhao, Maggie Thomas, Sarah M Spigelmyer, Nichlas J Sebree, Regan O Bales, Jamison B Burchett, Justen B Mamaril, Patrick A Limbach, Michael P Guy   +9 more
doaj   +1 more source

The first apicoplast tRNA thiouridylase plays a vital role in the growth of Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2022
Toxoplasmosis caused by the protozoan Toxoplasma gondii is one of the most common parasitic diseases in humans and almost all warm-blooded animals. Lys, Glu, and Gln-specific tRNAs contain a super-modified 2-thiourea (s2U) derivatives at the position 34,
Yimin Yang, Mi Lin, Xueqiu Chen, XianFeng Zhao, Lulu Chen, Mingxiu Zhao, Chaoqun Yao, Kaiyin Sheng, Yi Yang, Guangxu Ma, Aifang Du   +10 more
doaj   +1 more source

Temperature-dependent tRNA Modifications in Bacillales

International Journal of Molecular Sciences
Transfer RNA (tRNA) modifications are essential for the temperature adaptation of thermophilic and psychrophilic organisms, as they control the rigidity and flexibility of transcripts. To further understand how specific tRNA modifications are adjusted to maintain functionality in response to temperature fluctuations, we investigated whether tRNA ...
Anne Hoffmann, Christian Lorenz, Jörg Fallmann, Philippe Wolff, Antony Lechner, Heike Betat, Mario Mörl, Peter F. Stadler   +7 more
openaire   +4 more sources