Results 21 to 30 of about 764 (211)
Viruses, 2022 tRNA-derived RNA fragments (tRFs) are a recently discovered family of small noncoding RNAs (sncRNAs). We previously reported that respiratory syncytial virus (RSV) infection induces functional tRFs, which are derived from a limited subset of parent tRNAs,
Eun-Jin Choi +10 more
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Multiple Layers of Stress-Induced Regulation in tRNA Biology
Life, 2016 tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating ...
Hsiao-Yun Huang, Anita K. Hopper
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Posttranscriptional modification of tRNA in psychrophilic bacteria [PDF]
Journal of Bacteriology, 1997 Posttranscriptional modification in tRNA is known to play a multiplicity of functional roles, including maintenance of tertiary structure and cellular adaptation to environmental factors such as temperature. Nucleoside modification has been studied in unfractionated tRNA from three psychrophilic bacteria (ANT-300 and Vibrio sp.
J J, Dalluge +5 more
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Charging the code — tRNA modification complexes
Current Opinion in Structural Biology, 2019 All types of cellular RNAs are post-transcriptionally modified, constituting the so called 'epitranscriptome'. In particular, tRNAs and their anticodon stem loops represent major modification hotspots. The attachment of small chemical groups at the heart of the ribosomal decoding machinery can directly affect translational rates, reading frame ...
Rościsław Krutyhołowa +2 more
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TrmL and TusA Are Necessary for rpoS and MiaA Is Required for hfq Expression in Escherichia coli
Biomolecules, 2017 Previous work demonstrated that efficient RNA Polymerase sigma S-subunit (RpoS) translation requires the N6-isopentenyladenosine i6A37 transfer RNA (tRNA) modification for UUX-Leu decoding.
Joseph I. Aubee +2 more
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Inosine modifications in human tRNAs are incorporated at the precursor tRNA level [PDF]
Nucleic Acids Research, 2015 Transfer RNAs (tRNAs) are key adaptor molecules of the genetic code that are heavily modified post-transcriptionally. Inosine at the first residue of the anticodon (position 34; I34) is an essential widespread tRNA modification that has been poorly studied thus far.
Torres, Adrian Gabriel +8 more
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A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
eLife, 2023 Diverse chemical modifications fine-tune the function and metabolism of tRNA. Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have not been elucidated in most organisms ...
Francesca G Tomasi +3 more
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Biosynthesis and functions of sulfur modifications in tRNA [PDF]
Frontiers in Genetics, 2014 Sulfur is an essential element for a variety of cellular constituents in all living organisms. In tRNA molecules, there are many sulfur-containing nucleosides, such as the derivatives of 2-thiouridine (s(2)U), 4-thiouridine (s(4)U), 2-thiocytidine (s(2)C), and 2-methylthioadenosine (ms(2)A).
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Photoaffinity reagents for modification of aminoacyl‐tRNA synthetases [PDF]
FEBS Letters, 1974 Up to now, a few derivatives of aminoacyl-tRNA with a reactive group attached to the aminoacyl residue [l-4] and a reactive analog of an amino acid [4] have been used for the affinity labeling of aminoacyltRNA synthetases (EC 6.1 .l). For detailed investigation of the active centers of these enzymes, it is necessary to prepare tRNA analogs bearing ...
Budker, V.G. +5 more
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Toxics, 2019 Living organisms respond to environmental changes and xenobiotic exposures by regulating gene expression. While heat shock, unfolded protein, and DNA damage stress responses are well-studied at the levels of the transcriptome and proteome, tRNA-mediated ...
Sabrina M. Huber +3 more
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