Results 81 to 90 of about 5,172,961 (263)

Transchip: Single-molecule detection of transcriptional elongation complexes [PDF]

Analytical Biochemistry, 2007
A new single-molecule system, Transchip, was developed for analysis of transcription products at their genomic origins. The bacteriophage T7 RNA polymerase and its promoters were used in a model system, and resultant RNAs were imaged and detected at their positions along single template DNA molecules.
Tian, Wu, David C, Schwartz
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The multifunctional Ccr4–Not complex directly promotes transcription elongation [PDF]

Genes & Development, 2011
The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous. The discovery that Ccr4/Pop2 is the major cytoplasmic mRNA deadenylase and the detection of Not proteins within mRNA processing bodies have raised questions about the roles of the Ccr4–Not complex in ...
Jennifer A, Kruk, Arnob, Dutta, Jianhua, Fu, David S, Gilmour, Joseph C, Reese   +4 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Meta-regulation of Arabidopsis Auxin Responses Depends on tRNA Maturation

Cell Reports, 2015
Polar transport of the phytohormone auxin throughout plants shapes morphogenesis and is subject to stringent and specific control. Here, we identify basic cellular activities connected to translational control of gene expression as sufficient to specify ...
Johannes Leitner, Katarzyna Retzer, Nenad Malenica, Rasa Bartkeviciute, Doris Lucyshyn, Gunilla Jäger, Barbara Korbei, Anders Byström, Christian Luschnig   +8 more
doaj   +1 more source

The super elongation complex (SEC) and MLL in development and disease [PDF]

Genes & Development, 2011
Transcriptional regulation at the level of elongation is vital for the control of gene expression and metazoan development. The mixed lineage leukemia (MLL) protein and its Drosophila homolog, Trithorax, which exist within COMPASS (complex of proteins associated with Set1)-like complexes, are master regulators of development.
Edwin, Smith, Chengqi, Lin, Ali, Shilatifard   +2 more
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis [PDF]

, 2017
The Elongator complex (hereafter Elongator) promotes RNA polymerase II-mediated transcript elongation through epigenetic activities such as histone acetylation.
De Groeve, Steven, Sabine Le Gall, Alonso Baez, Luis, Dominique Van Der Straeten, Gagliardi, Olimpia, Van Der Straeten, Dominique, Olimpia Gagliardi, Pia Neyt, Jorge Fung, Mieke Van Lijsebettens, Paloma Mas, Lijsebettens, Mieke van, Fung, Jorge, Van Lijsebettens, Maria, Magdalena Woloszynska, Filip Vandenbussche, Le Gall, Sabine, Fung Uceda, Jorge Alberto, Luis Alonso Baez, Neyt, Pia, Van Lijsebettens, Mieke, Vandenbussche, Filip, Mas, Paloma, Steven De Groeve, Fung-Uceda, Jorge, Woloszynska, Magdalena, Baez, Luis Alonso   +26 more
core   +1 more source

The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase

Nature Communications, 2019
Elp3 is the catalytic subunit of the eukaryotic Elongator complex that catalyzes posttranscriptional tRNA modifications. Here the authors present the crystal structures of an acetyl-CoA analog bound bacterial Elp3 and a monomeric archaeal Elp3 and show ...
Ting-Yu Lin, Nour El Hana Abbassi, Karol Zakrzewski, Andrzej Chramiec-Głąbik, Małgorzata Jemioła-Rzemińska, Jan Różycki, Sebastian Glatt   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source