Results 111 to 120 of about 89,316 (267)
Advanced Science, EarlyView.RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu +7 more
wiley +1 more source
A Note on the Cowles-EM Algorithm for Bayesian Ordinal Probit Models
Research in StatisticsWe describe a novel procedure for Bayesian cutpoint simulation in ordered probit models. Our approach capitalizes upon a series of auxiliary binary probit models implied by the ordinal probit to craft tailored proposal distributions for Metropolis ...
Justin L. Tobias
doaj +1 more source
Metasurface‐Enabled Active‐Like Passive Radar
Advanced Science, EarlyView.A programmable space‐time‐coding metasurface embeds distinct spatiotemporal tags into ambient wireless signals, allowing passive radar to operate in an active‐like manner. By enabling code‐correlated reconstruction under interference, the approach supports robust real‐time UAV tracking in complex environments and points to intelligent, low‐power ...
Mingyi Li +7 more
wiley +1 more source
Inference in skew generalized t-link models for clustered binary outcome via a parameter-expanded EM algorithm. [PDF]
PLoS One, 2021 Tovissodé CF, Diop A, Glèlè Kakaï R.
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, EarlyView.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
On the Convergence of the EM Algorithm
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1983 SUMMARY An example is given showing that a sequence generated by a GEM algorthm need not converge under the conditions stated in Dempster et al., (1977). Two general convergence results are presented which suggest that in practice a GEM sequence will converge to a compact connected set of local maxima of the likelihood function; this ...
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
The EM Algorithm in Information Geometry
CoRRThe purpose of this thesis is to convey the basic concepts of information geometry and its applications to non-specialists and those in applied fields, assuming only a first-year undergraduate background in calculus, linear algebra, and probability theory / statistics.
openaire +2 more sources
Field‐Frustrated Cooperative Distortions: Suppressing Jahn‐Teller Ordering via Microwave Annealing
Advanced Science, EarlyView.Microwave annealing decouples local Jahn‐Teller distortions from long‐range cooperative ordering in CuFe2O4, stabilizing a metastable cubic phase that remains locally distorted yet globally symmetry‐frustrated. Synchrotron XRD, PDF, XPS, and in situ thermal cycling reveal how non‐equilibrium MW‐phonon interactions suppress cooperative orbital‐lattice ...
Daryoosh Vashaee, Kelvin Dsouza
wiley +1 more source
Advanced Science, EarlyView.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source