Results 111 to 120 of about 688,609 (284)
Stochastic Version of EM Algorithm for Nonlinear Random Change-Point Models. [PDF]
Proc Int Conf Stat Theory Appl ICSTA, 2021 Zhang H, Manandhar B.
europepmc +1 more source
On the Convergence Properties of the EM Algorithm
The Annals of Statistics, 1983 Two convergence aspects of the EM algorithm are studied: (i) does the EM algorithm find a local maximum or a stationary value of the (incomplete-data) likelihood function? (ii) does the sequence of parameter estimates generated by EM converge? Several convergence results are obtained under conditions that are applicable to many practical situations ...
openaire +3 more sources
Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
Advanced Science, EarlyView.This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh +11 more
wiley +1 more source
Forward and Backward Bellman Equations Improve the Efficiency of the EM Algorithm for DEC-POMDP. [PDF]
Entropy (Basel), 2021 Tottori T, Kobayashi TJ.
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Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
Classification of disease recurrence using transition likelihoods with expectation-maximization algorithm. [PDF]
Stat Med, 2022 Jiang H, Li Q, Lin JT, Lin FC.
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Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
New Vessel Extraction Method by Using Skew Normal Distribution for MRA Images
StatsVascular-related diseases pose significant public health challenges and are a leading cause of mortality and disability. Understanding the complex structure of the vascular system and its processes is crucial for addressing these issues.
Tohid Bahrami +3 more
doaj +1 more source
O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer
Advanced Science, EarlyView.This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu +10 more
wiley +1 more source
First-Order Learning Models With the GDINA: Estimation With the EM Algorithm and Applications. [PDF]
Appl Psychol Meas, 2021 Yigit HD, Douglas JA.
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