Results 121 to 130 of about 688,609 (284)
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)
Advanced Science, EarlyView.ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang +14 more
wiley +1 more source
EMeth: An EM algorithm for cell type decomposition based on DNA methylation data. [PDF]
Sci Rep, 2021 Zhang H, Cai R, Dai J, Sun W.
europepmc +1 more source
The Bayesian Structural EM Algorithm
CoRR, 2013 Appears in Proceedings of the Fourteenth Conference on Uncertainty in Artificial Intelligence (UAI1998)
openaire +3 more sources
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
EM algorithm for mixture of skew-normal distributions fitted to grouped data. [PDF]
J Appl Stat, 2021 Teimouri M.
europepmc +1 more source
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
A Note on the Cowles-EM Algorithm for Bayesian Ordinal Probit Models
Research in StatisticsWe describe a novel procedure for Bayesian cutpoint simulation in ordered probit models. Our approach capitalizes upon a series of auxiliary binary probit models implied by the ordinal probit to craft tailored proposal distributions for Metropolis ...
Justin L. Tobias
doaj +1 more source
Stochastic EM algorithm for generalized exponential cure rate model and an empirical study. [PDF]
J Appl Stat, 2021 Davies K, Pal S, Siddiqua JA.
europepmc +1 more source
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source