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EB lifetime distributions as alternative to the EP lifetime distributions
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2014 In this paper we consider lifetime distributions called EB-Max distribution and EB-Min. In the conditions of the Poisson’s Limit Theorem it is shown that EB-Max distribution may be approximated by its analogous called EP-Max lifetime distribution and EB ...
Lupu Carmen Elena +2 more
doaj +1 more source
Semi-Parametric Joint Modeling of Survival and Longitudinal Data: The R Package JSM
Journal of Statistical Software, 2020 This paper is devoted to the R package JSM which performs joint statistical modeling of survival and longitudinal data. In biomedical studies it has been increasingly common to collect both baseline and longitudinal covariates along with a possibly ...
Cong Xu +2 more
doaj +1 more source
MACOC: a medoid-based ACO clustering algorithm [PDF]
, 2014 The application of ACO-based algorithms in data mining is growing over the last few years and several supervised and unsupervised learning algorithms have been developed using this bio-inspired approach. Most recent works concerning unsupervised learning
Otero, Fernando E. B. +7 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Data Science JournalSophisticated data-intensive approaches have been widely applied in addressing air pollution problems, with applications ranging from remote sensing quantification of ground-level concentrations of atmospheric pollutants to associating particulate matter
Kassim Mwitondi, Hugo Wai Leung Mak
doaj +1 more source
Monotonicity properties of the Monte Carlo EM algorithm and connections with simulated likelihood [PDF]
, 2007 In this note we show that the Monte Carlo EM algorithm, appropriately constructed with importance re-weighting, monotonically increases a corresponding simulated likelihood.
Sermaidis, Giorgos +1 more
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Statistical inference for zero-and-one-inflated poisson models
Statistical Theory and Related Fields, 2017 In this paper, a zero-and-one-inflated Poisson (ZOIP) model is studied. The maximum likelihood estimation and the Bayesian estimation of the model parameters are obtained based on data augmentation method.
Yincai Tang, Wenchen Liu, Ancha Xu
doaj +1 more source
Comparison of the Average Kappa Coefficients of Two Binary Diagnostic Tests with Missing Data
Mathematics, 2021 The average kappa coefficient of a binary diagnostic test is a parameter that measures the average beyond-chance agreement between the diagnostic test and the gold standard.
José Antonio Roldán-Nofuentes +1 more
doaj +1 more source