Results 41 to 50 of about 89,585 (267)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Statistical inference for zero-and-one-inflated poisson models
Statistical Theory and Related Fields, 2017 In this paper, a zero-and-one-inflated Poisson (ZOIP) model is studied. The maximum likelihood estimation and the Bayesian estimation of the model parameters are obtained based on data augmentation method.
Yincai Tang, Wenchen Liu, Ancha Xu
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Improved Initialization of the EM Algorithm for Mixture Model Parameter Estimation
Mathematics, 2020 A commonly used tool for estimating the parameters of a mixture model is the Expectation−Maximization (EM) algorithm, which is an iterative procedure that can serve as a maximum-likelihood estimator.
Branislav Panić +2 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Divergence Family Contribution to Data Evaluation in Blockchain Via Alpha-EM and Log-EM Algorithms
IEEE Access, 2021 This study interrelates three adjacent topics in data evaluation. The first is the establishment of a relationship between Bregman divergence and probabilistic alpha-divergence.
Yasuo Matsuyama
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FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Maximum a posteriori Threshold Genomic Prediction Model for Ordinal Traits
G3: Genes, Genomes, Genetics, 2020 Due to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data.
Abelardo Montesinos-López +3 more
doaj +1 more source
Power of Error Correcting Codes for SFBC-OFDM Classification Over Unknown Channels
IEEE Access, 2022 The development of intelligent radios in wireless applications is mainly driven by the growing need for higher data rates, along with constrained spectrum resources.
Mohamed Marey, Hala Mostafa
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Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source