Results 41 to 50 of about 18,144,236 (296)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Quasi-Monte Carlo EM algorithm for MLEs in generalized linear mixed models

, 1998
Inferences for generalized linear mixed models are greatly hampered by the intractable integrated likelihood. In this paper numerical integration based on Quasi-Monte Carlo method is used to approximate the integral of the EM algorithm and then to fit ...
Robin Thompson, Thompson, R., Pan, J-X, Jian-Xin Pan   +3 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Joint Channel, Carrier-Frequency-Offset and Noise-Variance Estimation for OFDM Systems Based on Expectation Maximization [PDF]

, 2010
In this paper, a joint channel, carrier-frequency-offset (CFO) and noise-variance estimation scheme is proposed for OFDM systems which is based on Expectation and Maximization (EM) algorithm.
Xiaomin Mu, Jiankang Zhang, Mu, Xiaomin, Hanzo, Lajos, Lajos Hanzo, Zhang, Jiankang   +5 more
core   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Maximum a posteriori Threshold Genomic Prediction Model for Ordinal Traits

G3: Genes, Genomes, Genetics, 2020
Due to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data.
Abelardo Montesinos-López, Humberto Gutierrez-Pulido, Osval Antonio Montesinos-López, José Crossa   +3 more
doaj   +1 more source

Divergence Family Contribution to Data Evaluation in Blockchain Via Alpha-EM and Log-EM Algorithms

IEEE Access, 2021
This study interrelates three adjacent topics in data evaluation. The first is the establishment of a relationship between Bregman divergence and probabilistic alpha-divergence.
Yasuo Matsuyama
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Power of Error Correcting Codes for SFBC-OFDM Classification Over Unknown Channels

IEEE Access, 2022
The development of intelligent radios in wireless applications is mainly driven by the growing need for higher data rates, along with constrained spectrum resources.
Mohamed Marey, Hala Mostafa
doaj   +1 more source

Otimização de Coberturas em Aço de Edifícios Industriais [PDF]

, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro Tecnológico. Engenharia Civil.O presente trabalho apresenta um procedimento de otimização para estruturas de coberturas em aço de edifícios industrias.
Flôr, Mariane Isabel
core