Results 41 to 50 of about 620 (267)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

CORRELATION OF RADON AND SEISMIC ACTIVITY IN THE BAIKAL RIFT ZONE ACCORDING TO EMANATION MONITORING DATA

Геодинамика и тектонофизика
Long series of the emanation monitoring organized at Tyrgan (2018–2023), Buguldeika (2020–2023) and Maksimikha (2022–2023) stations in the central part of the Baikal Region (the Eastern Siberia) are studied to reveal the relationship of the subsurface ...
K. Zh. Seminsky, А. А. Bobrov
doaj   +1 more source

Deciphering and Predicting Microscale Controls on Radon Production in Soils, Sediments and Rock [PDF]

, 2018
Soils, sediments and rock are natural sources of radon (Rn), which poses an ongoing threat to human health. Numerous studies have measured Rn release from bulk earth materials, yet few have examined microscale controls on Rn flux from solids (emanation),
Kocar, Benjamin David, Mehta, Neha, Neha Mehta, Benjamin Kocar, Benjamin D. Kocar   +4 more
core   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

LXI. A comparison of the coefficients of diffusion of thorium and actinium emanations, with a note on their periods of transformation [PDF]

The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science, 1912
n ...
openaire   +1 more source

Decontamination of Sludgelike Uranium-Bearing Wastes: Decontamination Feasibility Judgment Using Radon Emanation Coefficients and Development of Decontamination Methods [PDF]

Journal of Nuclear Science and Technology, 2008
It is difficult to decontaminate sludgelike uranium-bearing wastes by wet methods, such as employing nitric acid for selective uranium dissolution. This is because these uranium-bearing wastes have very small pores inside which uranium is deposited, and the decontamination liquid cannot get inside the pores and so cannot dissolve the uranium.
Tomozo SASAKI, Mitsutaka IMAMURA, Yasuyoshi GUNJI, Takeshi OKUDA, Kenichi FUJIWARA, Masakazu TAKAI, Kazuhiro ARAI, Yoshin MORIGAKI   +7 more
openaire   +1 more source