Results 61 to 70 of about 51,799,739 (242)

A Decomposition-Based Development Method for Industrial Control Systems

IEEE Access, 2019
Industrial control systems (ICSs), especially distributed control systems (DCSs), are usually composed of several subsystems. Each subsystem is controlled by a control unit such as a programmable logic controller (PLC) or a micro-controller and ...
Jiawen Xiong, Ju Li, Jianqi Shi, Yanhong Huang   +3 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Model and Quality Driven Embedded Systems Engineering

, 2009
The world of embedded systems is broad and diverse, addressing a wide variety of application domains. Although technologically, the situation for embedded systems is still quite fragmented, platform-based engineering, reference designs and maturing ...
Vicedo, Josetxo, Tiensyrjä, Kari, Noguero, Adrian, Campos, Sergio, Ovaska, Eila, Pataricza, András, Balogh, András   +6 more
core   +1 more source

Healthcare systems collaborating to implement a shared decision‐making tool in the electronic health record and build evidence on its adoption and use

Learning Health Systems
Introduction Shared decision‐making (SDM) is a method of care by which patients and clinicians work together to co‐create a plan of care. Electronic health record (EHR) integration of SDM tools may increase adoption of SDM.
Megan E. Branda, Jennifer L. Ridgeway, Devin Mann, Jeff Wieser, Yvonne Gomez, Ashlee Dagoberg, Vivek Nautiyal, Hugh Jackson, Patrick Jahn, Kathy Yaple, Charanjit Khurana, Hooman Gharai, Briana Giese, Tate Corcoran, Victor Montori, Victor M. Montori   +15 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Advancing genomics research in Ireland: Part Two. Irish Health Research Forum report and recommendations [PDF]

, 2021
This report presents the proceedings of the Irish Health Research Forum on 12th May 2021. This is the second report to focus on advancing genetics and genomics in Ireland, and makes key recommendations for health research policy and practice in ...
Health Research Charities Ireland
core   +1 more source

A bridge between worlds: Embedding research in telepractice co‐design with disability community

Learning Health Systems
Introduction Co‐production approaches are increasingly being advocated for as a way of addressing the research translatory gap while including patient and public involvement in development of services they access, and particularly in disability service ...
Cloe Benz
doaj   +1 more source

Implementing Population Health Management (PHM) Across an Integrated Care System in England, Using Action Learning Sets and an Embedded, Formative Process Evaluation

International Journal of Integrated Care
Introduction: Population Health Management (PHM) is a UK priority for Integrated Care Systems (ICSs), aiming to deliver proactive, preventative, person-centred care using integrated health and care datasets. However, evidence on implementation in primary
Julian Elston, Felix Gradinger, Tahir Bockarie, Kristian Tomblin, Ginny Snaith, Richard Byng, Sheena Asthana   +6 more
doaj   +1 more source