Results 71 to 80 of about 1,607,682 (293)

Hybrid Improved Document-level Embedding (HIDE) [PDF]

arXiv, 2020
In recent times, word embeddings are taking a significant role in sentiment analysis. As the generation of word embeddings needs huge corpora, many applications use pretrained embeddings. In spite of the success, word embeddings suffers from certain drawbacks such as it does not capture sentiment information of a word, contextual information in terms ...
arxiv  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Meta-Learning With Relation Embedding for Few-Shot Deepfake Detection

IEEE Access
The generation of facial images via generative models has gained significant popularity, while the task of discriminating between authentic and synthetic faces has proven to be increasingly challenging. This challenge is exacerbated when novel generative
Xiaoyong Liu, Pengcheng Song, Pei Lu, Yanjun Wang   +3 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Active Contour Model Based on Local Intensity Fitting Energy for Image Segmentation and Bias Estimation

IEEE Access, 2018
Intensity nonuniformity is one of the common issues in image segmentation, which is caused by technical limitations or external interference. In this paper, a novel region-based active contour model is presented for interleaved segmentation of images ...
Xiaoying Shan, Xiaoliang Gong, Asoke K. Nandi   +2 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The Gauge Integral Theory in HOL4

Journal of Applied Mathematics, 2013
The integral is one of the most important foundations for modeling dynamical systems. The gauge integral is a generalization of the Riemann integral and the Lebesgue integral and applies to a much wider class of functions. In this paper, we formalize the
Zhiping Shi, Weiqing Gu, Xiaojuan Li, Yong Guan, Shiwei Ye, Jie Zhang, Hongxing Wei   +6 more
doaj   +1 more source

Accessible points of planar embeddings of tent inverse limit spaces [PDF]

arXiv, 2017
In this paper we study a class of embeddings of tent inverse limit spaces. We introduce techniques relying on the Milnor-Thurston kneading theory and use them to study sets of accessible points and prime ends of given embeddings. We completely characterize accessible points and prime ends of standard embeddings arising from the Barge-Martin ...
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source