Results 31 to 40 of about 604,815 (269)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Spinal Test Suites for Software Product Lines [PDF]
Electronic Proceedings in Theoretical Computer Science, 2014 A major challenge in testing software product lines is efficiency. In particular, testing a product line should take less effort than testing each and every product individually.
Harsh Beohar, Mohammad Reza Mousavi
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Industrial Experiences with a Formal DSL Semantics to Check the Correctness of DSL Artifacts [PDF]
Electronic Proceedings in Theoretical Computer Science, 2016 A domain specific language (DSL) abstracts from implementation details and is aligned with the way domain experts reason about a software component.
Sarmen Keshishzadeh +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Sensors, 2021 The photoplethysmographic (PPG) signal is an unobtrusive blood pulsewave measure that has recently gained popularity in the context of the Internet of Things.
Giulio Masinelli +3 more
doaj +1 more source
Medical Embedded Systems [PDF]
, 2007 Light-weight embedded systems are now gaining more popularity due to recent technological advances in fabrication of more powerful tiny processors. In particular, the field of pervasive computing and medical monitoring is emerging due to the development of tiny and low-profile computing nodes, mated with sensors and actuators, in close proximity to the
Roozbeh Jafari +2 more
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
IEEE AccessThe growth of safety-critical Internet of Things (IoT) applications, such as autonomous driving and industrial automation, demands predictable, real-time performance from distributed Edge-Fog-Cloud systems.
Josepaul Paulachan +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source